Recognition and clearance of apoptotic cells: a role for complement and pentraxins

被引：177

作者：

Nauta, AJ ^{[1
]}

Daha, MR ^{[1
]}

van Kooten, C ^{[1
]}

Roos, A ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Nephrol, NL-2300 RC Leiden, Netherlands

来源：

TRENDS IN IMMUNOLOGY | 2003年 / 24卷 / 03期

关键词：

D O I：

10.1016/S1471-4906(03)00030-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Apoptotic cells are specifically recognized and rapidly removed by professional phagocytes or neighboring cells by incompletely characterized mechanisms. Apoptotic cells are a potential source of autoantigens and, therefore, their efficient elimination, thus preventing unwanted immune reactions is essential. Accumulating evidence suggests that molecules of the innate immune system, including complement components and pentraxins, have. a role in the removal of apoptotic cells. Therefore, it has been postulated that in situations with massive apoptosis, defective removal of apoptotic material, as a result of hampered opsonization by pentraxins and complement, can lead to the development of an autoimmune response. In this Review the potential role of complement and pentraxins in the clearance of apoptotic cells will be discussed.

引用

页码：148 / 154

页数：7

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