Intrarenal Angiotensin II Augmentation in Hypertension

被引：2

作者：

Gonzalez-Villalobos, Romer A. ^{[1
]}

Navar, L. G. ^{[1
]}

机构：

[1] Tulane Univ, Dept Physiol, New Orleans, LA 70112 USA

来源：

LOCAL CARDIAC RENIN-ANGIOTENSIN ALDOSTERONE SYSTEM, SECOND EDITION | 2009年

关键词：

COLLECTING DUCT RENIN; ANG-II; CONVERTING ENZYME; AT(1) RECEPTORS; MEGALIN BINDS; EXPRESSION; KIDNEY; ENHANCEMENT; GENE; ACTIVATION;

D O I：

10.1007/978-1-4419-0528-4_12

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Angiotensin (Ang) II-dependent hypertension is characterized by an augmentation in intrarenal Ang II content beyond circulating, levels that is associated with functional and morphological derangements in the kidney. This augmentation is due to Am, II sequestration from the general circulation by the Ang II type I receptor (AT1R) and to intrarenal Ang II formation by a local renin-angiotensin system (RAS). This review summarizes the evidence in favor of the contribution of these two processes to the observed augmentation of intrarenal Angiotensin II as well as their impact on the regulation of kidney function and blood pressure regulation.

引用

页码：121 / 131

页数：11

共 40 条

[1] Apical ANG II-stimulated PLA(2) activity and Na+ flux: a potential role for Ca2+-independent PLA(2)
Becker, BN
Cheng, HF
Harris, RC
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 1997, 273 (04) : F554 - F562
[2] PROXIMAL TUBULAR SECRETION OF ANGIOTENSIN-II IN RATS
BRAAM, B
MITCHELL, KD
FOX, J
NAVAR, LG
[J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1993, 264 (05): : F891 - F898
[3] Effect of reduced angiotensin-converting enzyme gene expression and angiotensin-converting enzyme inhibition on angiotensin and bradykinin peptide levels in mice
Campbell, DJ
Alexiou, T
Xiao, HD
Fuchs, S
McKinley, MJ
Corvol, P
Bernstein, KE
[J]. HYPERTENSION, 2004, 43 (04) : 854 - 859
[4] Proximal tubular angiotensin II levels and renal functional responses to AT1 receptor blockade in nonclipped kidneys of goldblatt hypertensive rats
Cervenka, L
Wang, CT
Mitchell, KD
Navar, LG
[J]. HYPERTENSION, 1999, 33 (01) : 102 - 107
[5] Megalin binds and internalizes angiotensin-(1-7)
Gonzalez-Villalobos, R
Klassen, RB
Allen, PL
Johanson, K
Baker, CB
Kobori, H
Navar, LG
Hammond, TG
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2006, 290 (05) : F1270 - F1275
[6] Megalin binds and internalizes angiotensin II
Gonzalez-Villalobos, R
Klassen, RB
Allen, PL
Navar, LG
Hammond, TG
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2005, 288 (02) : F420 - F427
[7] Intrarenal angiotensin II and angiotensinogen augmentation in chronic angiotensin II-infused mice
Gonzalez-Villalobos, Romer A.
Seth, Dale M.
Satou, Ryousuke
Horton, Heather
Ohashi, Naro
Miyata, Kayoko
Katsurada, Akemi
Tran, Duy V.
Kobori, Hiroyuki
Navar, L. G.
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2008, 295 (03) : F772 - F779
[8] Angiotensin-Converting Enzyme-Derived Angiotensin II Formation During Angiotensin II-Induced Hypertension
Gonzalez-Villalobos, Romer A.
Satou, Ryousuke
Seth, Dale M.
Semprun-Prieto, Laura C.
Katsurada, Akemi
Kobori, Hiroyuki
Navar, L. Gabriel
[J]. HYPERTENSION, 2009, 53 (02) : 351 - 355
[9] Gonzalez-Villalobos RA, 2007, FASEB J, V21, pA1245
[10] ANGIOTENSIN AND ANGIOTENSIN CONVERTING ENZYME TISSUE-LEVELS IN 2-KIDNEY, ONE CLIP HYPERTENSIVE RATS
GUAN, S
FOX, J
MITCHELL, KD
NAVAR, LG
[J]. HYPERTENSION, 1992, 20 (06) : 763 - 767

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