A novel antiviral intervention results in more accurate assessment of human immunodeficiency virus type 1 replication dynamics and T-Cell decay in vivo

被引：300

作者：

Markowitz, M

Louie, M

Hurley, A

Sun, E

Di Mascio, M

机构：

[1] Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

[2] Abbott Labs, Abbott Pk, IL 60064 USA

[3] Los Alamos Natl Lab, Div Theoret, Los Alamos, NM USA

来源：

JOURNAL OF VIROLOGY | 2003年 / 77卷 / 08期

关键词：

D O I：

10.1128/JVI.77.8.5037-5038.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Mathematical models provide an understanding of in vivo replication kinetics of human immunodeficiency virus type 1 (HIV-1). With a novel intervention designed for increased potency, we have more accurately deduced the half-lives of virus-producing CD4+ T cells, 0.7 day, and the generation time of HIV-1 in vivo, approximately 2 days, confirming the dynamic nature of HIV-1 replication.

引用

页码：5037 / 5038

页数：2

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