We investigated the involvement of endothelin, receptor signals in the activation of astrocytes in vitro and in vivo. Endothelin reversed the stellate morphology of astrocytes induced by several agents. Endothelin stimulates astrocytic stress fiber formation. This effect of endothelin is Ca2+-independent and mediated by rho protein striatum caused reactive astrocytosis which is prevented by a systemic injection of endothelin, receptor antagonist. We propose the role of endothelin, receptor signal transduction in reactive astrocytes.
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COLUMBIA UNIV COLL PHYS & SURG, CTR NEUROBIOL & BEHAV, NEW YORK, NY 10032 USACOLUMBIA UNIV COLL PHYS & SURG, CTR NEUROBIOL & BEHAV, NEW YORK, NY 10032 USA
BAORTO, DM
MELLADO, W
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COLUMBIA UNIV COLL PHYS & SURG, CTR NEUROBIOL & BEHAV, NEW YORK, NY 10032 USACOLUMBIA UNIV COLL PHYS & SURG, CTR NEUROBIOL & BEHAV, NEW YORK, NY 10032 USA
MELLADO, W
SHELANSKI, ML
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机构:
COLUMBIA UNIV COLL PHYS & SURG, CTR NEUROBIOL & BEHAV, NEW YORK, NY 10032 USACOLUMBIA UNIV COLL PHYS & SURG, CTR NEUROBIOL & BEHAV, NEW YORK, NY 10032 USA
机构:
COLUMBIA UNIV COLL PHYS & SURG, CTR NEUROBIOL & BEHAV, NEW YORK, NY 10032 USACOLUMBIA UNIV COLL PHYS & SURG, CTR NEUROBIOL & BEHAV, NEW YORK, NY 10032 USA
BAORTO, DM
MELLADO, W
论文数: 0引用数: 0
h-index: 0
机构:
COLUMBIA UNIV COLL PHYS & SURG, CTR NEUROBIOL & BEHAV, NEW YORK, NY 10032 USACOLUMBIA UNIV COLL PHYS & SURG, CTR NEUROBIOL & BEHAV, NEW YORK, NY 10032 USA
MELLADO, W
SHELANSKI, ML
论文数: 0引用数: 0
h-index: 0
机构:
COLUMBIA UNIV COLL PHYS & SURG, CTR NEUROBIOL & BEHAV, NEW YORK, NY 10032 USACOLUMBIA UNIV COLL PHYS & SURG, CTR NEUROBIOL & BEHAV, NEW YORK, NY 10032 USA