Role of endothelin B receptor signals in reactive astrocytes

被引：30

作者：

Baba, A ^{[1
]}

机构：

[1] Osaka Univ, Fac Pharmaceut Sci, Dept Pharmacol, Suita, Osaka 565, Japan

来源：

LIFE SCIENCES | 1998年 / 62卷 / 17-18期

关键词：

endothelin; astrocytes; actin; rho;

D O I：

10.1016/S0024-3205(98)00133-7

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We investigated the involvement of endothelin, receptor signals in the activation of astrocytes in vitro and in vivo. Endothelin reversed the stellate morphology of astrocytes induced by several agents. Endothelin stimulates astrocytic stress fiber formation. This effect of endothelin is Ca2+-independent and mediated by rho protein striatum caused reactive astrocytosis which is prevented by a systemic injection of endothelin, receptor antagonist. We propose the role of endothelin, receptor signal transduction in reactive astrocytes.

引用

页码：1711 / 1715

页数：5

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