Role of endothelin B receptor signals in reactive astrocytes

被引:30
作者
Baba, A [1 ]
机构
[1] Osaka Univ, Fac Pharmaceut Sci, Dept Pharmacol, Suita, Osaka 565, Japan
关键词
endothelin; astrocytes; actin; rho;
D O I
10.1016/S0024-3205(98)00133-7
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
We investigated the involvement of endothelin, receptor signals in the activation of astrocytes in vitro and in vivo. Endothelin reversed the stellate morphology of astrocytes induced by several agents. Endothelin stimulates astrocytic stress fiber formation. This effect of endothelin is Ca2+-independent and mediated by rho protein striatum caused reactive astrocytosis which is prevented by a systemic injection of endothelin, receptor antagonist. We propose the role of endothelin, receptor signal transduction in reactive astrocytes.
引用
收藏
页码:1711 / 1715
页数:5
相关论文
共 25 条
  • [1] ASTROCYTE PROCESS GROWTH INDUCTION BY ACTIN BREAKDOWN
    BAORTO, DM
    MELLADO, W
    SHELANSKI, ML
    [J]. JOURNAL OF CELL BIOLOGY, 1992, 117 (02) : 357 - 367
  • [2] ENDOTHELIN LEVELS INCREASE IN RAT FOCAL AND GLOBAL-ISCHEMIA
    BARONE, FC
    GLOBUS, MYT
    PRICE, WJ
    WHITE, RF
    STORER, BL
    FEUERSTEIN, GZ
    BUSTO, R
    OHLSTEIN, EH
    [J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1994, 14 (02) : 337 - 342
  • [3] GIULIAN D, 1989, J NEUROSCI, V9, P4416
  • [4] CYCLIC AMP-INDUCED SHAPE CHANGES OF ASTROCYTES ARE ACCOMPANIED BY RAPID DEPOLYMERIZATION OF ACTIN
    GOLDMAN, JE
    ABRAMSON, B
    [J]. BRAIN RESEARCH, 1990, 528 (02) : 189 - 196
  • [5] GUTOWSKI S, 1991, J BIOL CHEM, V266, P20519
  • [6] ACTION OF ENDOTHELIN-1 ON RAT ASTROCYTES THROUGH THE ETB RECEPTOR
    HAMA, H
    SAKURAI, T
    KASUYA, Y
    FUJIKI, M
    MASAKI, T
    GOTO, K
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 186 (01) : 355 - 362
  • [7] DISTINCT TISSUE DISTRIBUTION AND CELLULAR-LOCALIZATION OF 2 MESSENGER RIBONUCLEIC-ACIDS ENCODING DIFFERENT SUBTYPES OF RAT ENDOTHELIN RECEPTORS
    HORI, S
    KOMATSU, Y
    SHIGEMOTO, R
    MIZUNO, N
    NAKANISHI, S
    [J]. ENDOCRINOLOGY, 1992, 130 (04) : 1885 - 1895
  • [8] BIOCHEMICAL AND PHARMACOLOGICAL PROFILE OF A POTENT AND SELECTIVE ENDOTHELIN B-RECEPTOR ANTAGONIST, BQ-788
    ISHIKAWA, K
    IHARA, M
    NOGUCHI, K
    MASE, T
    MINO, N
    SAEKI, T
    FUKURODA, T
    FUKAMI, T
    OZAKI, S
    NAGASE, T
    NISHIKIBE, M
    YANO, M
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (11) : 4892 - 4896
  • [9] Endothelins promote the activation of astrocytes in rat neostriatum through ETB receptors
    Ishikawa, N
    Takemura, M
    Koyama, Y
    Shigenaga, Y
    Okada, T
    Baba, A
    [J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 1997, 9 (05) : 895 - 901
  • [10] Inhibition of vanadate-induced astrocytic stress fiber formation by C3 ADP-ribosyltransferase
    Koyama, Y
    Fukuda, T
    Baba, A
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 218 (01) : 331 - 336