Catechol-O-methyltransferase genotype and susceptibility to Parkinson's disease in Japan - Short communication

被引：53

作者：

Yoritaka, A ^{[1
]}

Hattori, N ^{[1
]}

Yoshino, H ^{[1
]}

Mizuno, Y ^{[1
]}

机构：

[1] Juntendo Univ, Sch Med, Dept Neurol, Bunkyo Ku, Tokyo 113, Japan

来源：

JOURNAL OF NEURAL TRANSMISSION | 1997年 / 104卷 / 11-12期

关键词：

catechol-O-methyltransferase; polymorphism; Parkinson's disease;

D O I：

10.1007/BF01294732

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report -108Met/Val polymorphism of the COMT gene in Japanese patients with Parkinson's disease (PD). The allele frequency for -108Val was higher in PD patients compared with controls, although the differences did not reach the statistical significance. However, the frequency of -108Val homozygotes was significantly higher in PD patients (56.8%) than in control subjects (44.2%), and heterozygotes of -108Met/Val were less in PD. COMT gene polymorphism may constitute a genetic risk factor for PD among Japanese.

引用

页码：1313 / 1317

页数：5

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