Ecologic genomics of DNA: Upstream bending in prokaryotic promoters

被引：35

作者：

Bolshoy, A ^{[1
]}

Nevo, E ^{[1
]}

机构：

[1] Univ Haifa, Inst Evolut, IL-31905 Haifa, Israel

来源：

GENOME RESEARCH | 2000年 / 10卷 / 08期

关键词：

D O I：

10.1101/gr.10.8.1185

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

After our analysis of the distribution of predicted intrinsic curvature along all available complete prokaryotic genomes, the genomes were divided into two groups. Curvature distribution in all prokaryotes of the first group indicated a substantial fraction of promoters characterized by intrinsic DNA curvature located within or upstream of the promoter region. We did not find this peculiar DNA curvature distribution in prokaryotes in the second group. Remarkably, all bacteria of the first group were mesophilic, whereas many prokaryotes of the second group were hyperthermophilic. We hypothesize that DNA curvature plays a biologic role in gene regulation in mesophilic as opposed to hyperthermophilic prokaryotes, i.e., DNA curvature presumably has a functional adaptive significance determined by temperature selection.

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页码：1185 / 1193

页数：9

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