Generation of metalloenamines by carbon-carbon bond formation: ring opening reactions of 2-methyleneaziridines with organometallic reagents

被引：29

作者：

Hayes, JF

Shipman, M ^{[1
]}

Twin, H

机构：

[1] Univ Exeter, Sch Chem, Exeter EX4 4QD, Devon, England

[2] SmithKline Beecham Pharmaceut, Tonbridge TN11 9AN, Kent, England

来源：

CHEMICAL COMMUNICATIONS | 2000年 / 18期

关键词：

D O I：

10.1039/b005623p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ring opening of 2-methyleneaziridines with Grignard reagents in the presence of CuI yields metalloenamines in a regiospecific fashion which can be further reacted with electrophiles to produce functionalised ketones via a one-pot process.

引用

页码：1791 / 1792

页数：2

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