Endotoxin recognition and signal transduction by the TLR4/MD-2 complex

被引：236

作者：

Fitzgerald, KA ^{[1
]}

Rowe, DC ^{[1
]}

Golenbock, DT ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Div Infect Dis & Immunol, Worcester, MA 01605 USA

来源：

MICROBES AND INFECTION | 2004年 / 6卷 / 15期

关键词：

endotoxin; TLR; IRF; signaling;

D O I：

10.1016/j.micinf.2004.08.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Bacterial lipopolysaccharides are recognized in mammals by a receptor complex composed of CD14, Toll-like receptor (TLR)-4 and MD-2. Transduction of signaling is achieved following the recruitment of a combination of four Toll-interleukin-1 resistance (TIR)-domain-containing adapter molecules, which provide a structural platform enabling the recruitment and activation of downstream effectors essential for pathway-specific transcription factor activation and inflammatory gene expression. (C) 2004 Published by Elsevier SAS.

引用

页码：1361 / 1367

页数：7

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