Development of a dual recombinant vaccine to protect small ruminants against peste-des-petits-ruminants virus and capripoxvirus infections

被引：96

作者：

Berhe, G

Minet, C

Le Goff, C

Barrett, T

Ngangnou, A

Grillet, C

Libeau, G

Fleming, M

Black, DN

Diallo, A

机构：

[1] Cirad, Programme St Anim, F-34398 Montpellier 05, France

[2] Pirbright Lab, Inst Anim Hlth, Surrey GU24 ONF, England

[3] LANAVET, Garoua, Cameroon

来源：

JOURNAL OF VIROLOGY | 2003年 / 77卷 / 02期

关键词：

D O I：

10.1128/JVI.77.2.1571-1577.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A recombinant capripoxvirus vaccine containing a cDNA of the peste-des-petits-ruminants virus (PPRV) fusion protein gene was constructed. A quick and efficient method was used to select a highly purified recombinant virus clone. A trial showed that a dose of this recombinant as low as 0.1 PFU protected goats against challenge with a virulent PPRV strain.

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页码：1571 / 1577

页数：7

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