Brief report: Association of sex chromosome anomalies with childhood-onset psychotic disorders

被引:42
作者
Kumra, S
Wiggs, E
Krasnewich, D
Meck, J
Smith, ACM
Bedwell, J
Fernandez, T
Jacobsen, LK
Lenane, M
Rapoport, JL
机构
[1] NIMH, Child Psychiat Branch, Bethesda, MD 20892 USA
[2] Georgetown Univ, Med Ctr, Dept Obstet & Gynecol, Washington, DC 20007 USA
[3] NIMH, Child Neurosci Branch, Bethesda, MD 20892 USA
关键词
sex chromosome anomalies; childhood-onset psychotic disorders; neurodevelopmental impairments;
D O I
10.1097/00004583-199803000-00014
中图分类号
B844 [发展心理学(人类心理学)];
学科分类号
040202 ;
摘要
Objective: An apparent excess of sex chromosome aneuploidies (XXY, XXX, and possibly XYY) has been reported in patients with adult-onset schizophrenia and with unspecified psychoses. This study describes the results of cytogenetic screening carried out for pediatric patients meeting DSM-III-R criteria for childhood-onset schizophrenia (COS) and a subgroup of patients with childhood-onset psychotic disorder not otherwise specified, provisionally labeled by the authors as multidimensionally impaired (MDI). Method: From August 1990 to July 1997, karyotypes were determined for 66 neuroleptic-nonresponsive pediatric patients (28 MDI, 38 COS), referred to the National Institute of Mental Health for an inpatient treatment trial of clozapine. Results: Four (6.1%) of 66 patients (3 MDI, 1 COS) were found to have sex chromosome anomalies (mosaic 47,XXY; 47,XXY; 47,XYY; mosaic 45,XO, respectively), which is higher than the expected rate of 1 per 426 children or 2.34 per 1,000 in the general population (4/66 versus 1/426, chi(2) = 19.2, df = 1, p = .00001). All cases had been previously undiagnosed. Conclusions: These findings lend support to a hypothesis that a loss of balance of gene products on the sex chromosomes may predispose affected individuals to susceptibility to additional genetic and environmental insults that result in childhood-onset psychotic disorders. Karyotyping of children with psychotic disorders should be routine.
引用
收藏
页码:292 / 296
页数:5
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