High throughput analysis and purification in support of automated parallel synthesis

被引：53

作者：

Weller, HN

Young, MG

Michalczyk, SJ

Reitnauer, GH

Cooley, RS

Rahn, PC

Loyd, DJ

Fiore, D

Fischman, SJ

机构：

[1] Bristol Myers Squibb Pharmaceut Res Inst, Instrument Dev Grp, Princeton, NJ 08543 USA

[2] YMC Inc, Wilmington, NC 28403 USA

[3] Shimadzu Sci Instruments Inc, Columbia, MD 21046 USA

来源：

MOLECULAR DIVERSITY | 1997年 / 3卷 / 01期

关键词：

combinatorial chemistry; combinatorial library; purification HPLC; preparative HPLC;

D O I：

10.1023/A:1009636725336

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rapid reverse-phase analytical and preparative HPLC methods have been developed for application to parallel synthesis libraries. Gradient methods, short columns, and high flow rates allow analysis of over 300 compounds per day on a single system, or purification of up to 200 compounds per day on a single preparative system. Hardware and software modifications allow continuous unattended use for maximum efficiency and throughput.

引用

页码：61 / 70

页数：10

共 23 条

[1] SYNTHESIS OF A SMALL-MOLECULE COMBINATORIAL LIBRARY ENCODED WITH MOLECULAR TAGS [J].