LaB6 surface chemistry-reinforced scaffolds for treating bone tumors and bone defects

被引：47

作者：

Dang, Wentao ^{[1
,2
]}

Ma, Bing ^{[1
]}

Huan, Zhiguang ^{[1
]}

Lin, Rongcai ^{[1
]}

Wang, Xiaoya ^{[1
]}

Li, Tian ^{[1
,2
]}

Wu, Jinfu ^{[1
,2
]}

Ma, Nan ^{[3
]}

Zhu, Haibo ^{[3
]}

Chang, Jiang ^{[1
]}

Wu, Chengtie ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

[2] Univ Chinese Acad Sci, Ctr Mat Sci & Optoelect Engn, Beijing 100049, Peoples R China

[3] Shanghai Jiao Tong Univ, Xuhui Dist Cent Hosp, Sch Med, Shanghai Peoples Hosp 6, Shanghai 200031, Peoples R China

来源：

APPLIED MATERIALS TODAY | 2019年 / 16卷

基金：

中国国家自然科学基金;

关键词：

LaB6; Scaffold; Bone tumor; Bone defect; MESENCHYMAL STEM-CELLS; IN-VITRO; NANOPARTICLES; LANTHANIDE; THERAPY; RESORPTION; STRENGTH; CANCER; DIFFERENTIATION; NANOCRYSTALS;

D O I：

10.1016/j.apmt.2019.04.015

中图分类号：

T [工业技术];

学科分类号：

120111 [工业工程];

摘要：

Bone tumors may lead to osteoporosis. It is of great significance to fabricate functional scaffolds for treating bone tumor, osteoporosis and repairing bone defects. In this study, LaB 6 micro-nanoparticles/poly(D,L-lactide)-modified p-tricalcium phosphate scaffolds (TCP-PDLLA-LB) were successfully prepared. The LaB6 surface chemistry-reinforced TCP-PDLLA-LB scaffolds were endowed with the following excellent properties: (1) the enhanced mechanical strength. The TCP-PDLLA-5LB scaffolds possessed higher compression resistant capacity than TCP scaffolds owing to the strong adhesive property of PDLLA that bound the LaB(6 )micro-nanoparticles and scaffolds tightly; (2) the excellent photothermal performance. TCP-PDLLA-LB scaffolds presented distinct photothermal property because of localized surface plasmon resonance effect of LaB(6 )micro-nanoparticles when exposed to the nearinfrared (NIR) light (wavelength: 808 nm) and it was flexibly controllable through changing the quantity of LaB6 micro-nanoparticles, power density of NIR light and environmental humidity; (3) the excellent biological properties in vitro. When culturing with saos-2 bone tumor cells, the TCP-PDLLA-5LB scaffolds effectively killed the saos-2 cells through adjusting power density of NIR light, irradiation duration time of NIR light and irradiation times of NIR light. Additionally, the TCP-PDLLA-5LB scaffolds were able to release bioactive ions which were beneficial to the in vitro osteogenesis of rabbit bone marrow stromal cells (rBMSCs) by supporting the attachment and proliferation of rBMSCs as well as promoting the expressions of osteogenic genes BMP2, RUNX2 and COL 1; and (4) the abilities of effectively ablating bone tumors and supporting bone tissue regeneration in vivo. The bone tumor tissues were significantly ablated and suppressed through hyperthermia due to the existence of LaB6 micro-nanoparticles on the scaffolds. Simultaneously, TCP-PDLLA-5LB scaffolds implanted in bone defects effectively helped new bone formation regardless of NIR light irradiation. In conclusion, LaB6 surface chemistry-reinforced scaffolds possess the dual functions of ablating bone tumor and repairing bone defects, which offers a promising therapy strategy for tumor/disease-related bone tissue engineering. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页码：42 / 55

页数：14

共 62 条

[1]

Atherton D., 2006, Treatment of Bone Disorders, Patent No. [US7078059 B2, 7078059]

[2]

Barta CA, 2007, DALTON T, P5019, DOI 10.1039/b705123a

[3]

Bone morphogenetic protein 7: A broad-spectrum growth factor with multiple target therapeutic potency [J].

Boon, Mariette R. ;

van der Horst, Geertje ;

van der Pluijm, Gabri ;

Tamsma, Jouke T. ;

Smit, Johannes W. A. ;

Rensen, Patrick C. N. .

CYTOKINE & GROWTH FACTOR REVIEWS, 2011, 22 (04) :221-229

[4]

Bone tissue engineering using 3D printing [J].

Bose, Susmita ;

Vahabzadeh, Sahar ;

Bandyopadhyay, Amit .

MATERIALS TODAY, 2013, 16 (12) :496-504

[5]

Boskey A.L., 2013, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, P49, DOI [10.1002/9781119266594.ch11, DOI 10.1002/9781119266594.CH11]

[6]

In vivo study and thermodynamic investigation of two lanthanum complexes, La(dpp)3 and La(XT), for the treatment of bone resorption disorders [J].