Closing the GAP: A role for a RhoA GAP in cytokinesis

被引:25
作者
Maddox, AS [1 ]
Oegema, K [1 ]
机构
[1] Univ Calif San Diego, Ludwig Inst Canc Res, La Jolla, CA 92093 USA
关键词
D O I
10.1016/S1097-2765(03)00151-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
During cell division, cytokinesis partitions the cytoplasm to form two daughter cells. Recently in Developmental Cell, Minoshima et al. (2003) establish an important connection between three regulatory molecules that coordinate this process, showing that the mitotic kinase aurora B phosphorylates MgcRacGAP to convert it to a GAP for RhoA, a small GTPase that drives cytokinesis.
引用
收藏
页码:846 / 848
页数:3
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