Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health

被引：500

作者：

Meaney, Michael J. ^{[1
]}

Szyf, Moshe

Seckl, Jonathan R.

机构：

[1] McGill Univ, McGill Program Study Genes Environm & Hlth, Montreal, PQ, Canada

[2] McGill Univ, Dept Psychiat, Montreal, PQ, Canada

[3] McGill Univ, Dept Pharmacol & Therapeut, Montreal, PQ, Canada

[4] Univ Edinburgh, Queens Med Res Inst, Endocrinol Unit, Edinburgh, Midlothian, Scotland

来源：

TRENDS IN MOLECULAR MEDICINE | 2007年 / 13卷 / 07期

关键词：

D O I：

10.1016/j.molmed.2007.05.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Environmental effects on the materno-foetal interaction determine birth outcomes that predict health over the lifespan. Thus, maternal undernutrition or stress associate with low birth weight, leading to an increased risk of metabolic and cardiovascular illness in the offspring. We argue that these effects are, in part, mediated by direct and indirect effects on the hypothalamic-pituitary-adrenal (HPA) axis such that (i) the effect of maternal adversity on foetal growth is mediated by adrenal glucocorticoids and (ii) environmental adversity alters maternal physiology and behaviour, which then programs HPA activity in the offspring.

引用

页码：269 / 277

页数：9

共 90 条

[1] TYPE 2 (NON-INSULIN-DEPENDENT) DIABETES-MELLITUS, HYPERTENSION AND HYPERLIPEMIA (SYNDROME-X) - RELATION TO REDUCED FETAL GROWTH [J].

BARKER, DJP ;

HALES, CN ;

FALL, CHD ;

OSMOND, C ;

PHIPPS, K ;

CLARK, PMS .

DIABETOLOGIA, 1993, 36 (01) :62-67

[2] FETAL NUTRITION AND CARDIOVASCULAR-DISEASE IN ADULT LIFE [J].

BARKER, DJP ;

GLUCKMAN, PD ;

GODFREY, KM ;

HARDING, JE ;

OWENS, JA ;

ROBINSON, JS .

LANCET, 1993, 341 (8850) :938-941

[3] GLUCOCORTICOID EXPOSURE INUTERO - NEW MODEL FOR ADULT HYPERTENSION [J].

BENEDIKTSSON, R ;

LINDSAY, RS ;

NOBLE, J ;

SECKL, JR ;

EDWARDS, CRW .

LANCET, 1993, 341 (8841) :339-341

[4] Placental 11 beta-hydroxysteroid dehydrogenase: A key regulator of fetal glucocorticoid exposure [J].

Benediktsson, R ;

Calder, AA ;

Edwards, CRW ;

Seckl, JR .

CLINICAL ENDOCRINOLOGY, 1997, 46 (02) :161-166

[5] FETAL OSTEOCALCIN LEVELS ARE RELATED TO PLACENTAL 11-BETA-HYDROXYSTEROID DEHYDROGENASE-ACTIVITY IN HUMANS [J].

BENEDIKTSSON, R ;

BRENNAND, J ;

TIBI, L ;

CALDER, AA ;

SECKL, JR ;

EDWARDS, CRW .

CLINICAL ENDOCRINOLOGY, 1995, 42 (05) :551-555

[6] Preterm newborn lamb renal and cardiovascular responses after fetal or maternal antenatal betamethasone [J].

Berry, LM ;

Polk, DH ;

Ikegami, M ;

Jobe, AH ;

Padbury, JF ;

Ervin, MG .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1997, 272 (06) :R1972-R1979

[7] FETAL DEXAMETHASONE EXPOSURE INTERFERES WITH ESTABLISHMENT OF CARDIAC NORADRENERGIC INNERVATION AND SYMPATHETIC ACTIVITY [J].

BIAN, XP ;

SEIDLER, FJ ;

SLOTKIN, TA .

TERATOLOGY, 1993, 47 (02) :109-117

[8] Methylation-induced repression - Belts, braces, and chromatin [J].

Bird, AP ;

Wolffe, AP .

CELL, 1999, 99 (05) :451-454

[9] Glucocorticoids impair fetal β-cell development in rats [J].

Blondeau, B ;

Lesage, J ;

Czernichow, P ;

Dupouy, JP ;

Bráant, B .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2001, 281 (03) :E592-E599

[10] The ontogeny of 11 beta-hydroxysteroid dehydrogenase type 2 and mineralocorticoid receptor gene expression reveal intricate control of glucocorticoid action in development. [J].

Brown, RW ;

Diaz, R ;

Robson, AC ;

Kotelevtsev, YV ;

Mullins, JJ ;

Kaufman, MH ;

Seckl, JR .

ENDOCRINOLOGY, 1996, 137 (02) :794-797

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