Control of viral rebound through therapeutic immunization with DermaVir

被引：55

作者：

Lisziewicz, J

Trocio, J

Xu, JQ

Whitman, L

Ryder, A

Bakare, N

Lewis, MG

Wagner, W

Pistorio, A

Arya, S

Lori, F

机构：

[1] RIGHT, Washington, DC 20007 USA

[2] Genet Immunol LLC, Washington, DC USA

[3] So Res Inst, Frederick, MD USA

[4] IRCCS G Gaslini, Clin Epidemiol & Biometry Unit, Genoa, Italy

[5] NCI, NIH, Bethesda, MD 20892 USA

来源：

AIDS | 2005年 / 19卷 / 01期

关键词：

dendritic cells; HIV therapy; vaccine;

D O I：

10.1097/00002030-200501030-00004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Objective: To reconstitute immune responses capable of eliminating infected cells and suppressing viral load during chronic retroviral infection. Design: A topical, DNA-based therapeutic immunization (DermaVir) was designed to express most of the regulatory and structural viral genes in dendritic cells. Methods: DermaVir alone and in combination with antiretroviral drugs was tested in chronically SIV-infected macaques. Results: DermaVir provided virological, immunological and clinical benefit for SIV-infected macaques during chronic infection and AIDS. In combination with antiretroviral drugs, DermaVir augmented SIV-specific T-cell responses and enhanced control of viral load rebound during treatment interruptions. Conclusions: The results indicate the feasibility of therapeutic immunization even in immune compromised hosts, and suggest that DermaVir can complement antiretroviral drugs to sustain suppression of HIV-1 replication. (C) 2005 Lippincott Williams Wilkins.

引用

页码：35 / 43

页数：9

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