Use of G-CSF for granulocyte transfusion therapy

被引:6
作者
Hübel, K
Dale, DC
Engert, A
Liles, WC
机构
[1] Univ Washington, Dept Med, Div Infect Dis, Seattle, WA 98195 USA
[2] Univ Cologne, Dept Internal Med 1, D-5000 Cologne 41, Germany
关键词
G-CSF; granulocytes; infection; neutropenia; transfusion;
D O I
10.1080/13684730050515813
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Patients with neutropenia, especially neutropenia following aggressive myeloablative therapy, are at high risk for developing infectious complications caused by bacteria and opportunistic fungi. Infections remain one of the leading causes of treatment failure in patients with cancer. Thus, new and innovative therapeutic strategies are needed for management of neutropenic patients with infection. Because neutrophils represent the first line of host defense, granulocyte transfusion therapy should be a logical therapeutic approach. Although such therapy has been employed sporadically for several decades, clinical benefit has been compromised by technical problems and low granulocyte yields resulting from inadequate donor stimulation. The discovery of granulocyte colony-stimulatng factor (G-CSF) as a means to elevate blood neutrophil counts when administered to normal donors has rekindled interest in granulocyte transfusion therapy. Extensive experience has been gained worldwide with G-CSF in clinical practice, and adverse events have been minimal when G-CSF has been administered to patients or healthy persons in human trials. This review focuses on the use of G-CSF in granulocyte transfusion therapy, including technical considerations of granulocyte leukapheresis and storage, donor selection and stimulation, as well as treatment results and associated risks.
引用
收藏
页码:89 / 95
页数:7
相关论文
共 68 条
[1]   RANDOMIZED CLINICAL-TRIAL OF GRANULOCYTE TRANSFUSIONS FOR INFECTION IN ACUTE-LEUKEMIA [J].
ALAVI, JB ;
ROOT, RK ;
DJERASSI, I ;
EVANS, AE ;
GLUCKMAN, SJ ;
MACGREGOR, RR ;
GUERRY, D ;
SCHREIBER, AD ;
SHAW, JM ;
KOCH, P ;
COOPER, RA .
NEW ENGLAND JOURNAL OF MEDICINE, 1977, 296 (13) :706-711
[2]   In vivo effects of recombinant human granulocyte colony-stimulating factor on neutrophil oxidative functions in normal human volunteers [J].
Allen, RC ;
Stevens, PR ;
Price, TH ;
Chatta, GS ;
Dale, DC .
JOURNAL OF INFECTIOUS DISEASES, 1997, 175 (05) :1184-1192
[3]   GM-CSF THERAPY AND CAPILLARY-LEAK SYNDROME [J].
ARNING, M ;
KLICHE, KO ;
SCHNEIDER, W .
ANNALS OF HEMATOLOGY, 1991, 62 (2-3) :83-83
[4]   THE EFFECTS OF DAILY RECOMBINANT HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR ADMINISTRATION ON NORMAL GRANULOCYTE DONORS UNDERGOING LEUKAPHERESIS [J].
BENSINGER, WI ;
PRICE, TH ;
DALE, DC ;
APPELBAUM, FR ;
CLIFT, R ;
LILLEBY, K ;
WILLIAMS, B ;
STORB, R ;
THOMAS, ED ;
BUCKNER, CD .
BLOOD, 1993, 81 (07) :1883-1888
[5]   TRANSFUSION OF NEUTROPHILS AS PREVENTION OR TREATMENT OF INFECTION IN PATIENTS WITH NEUTROPENIA [J].
BOGGS, DR .
NEW ENGLAND JOURNAL OF MEDICINE, 1974, 290 (19) :1055-1062
[6]   Human monocytes express functional receptors for granulocyte colony-stimulating factor that mediate suppression of monokines and interferon-γ [J].
Boneberg, EM ;
Hareng, L ;
Gantner, F ;
Wendel, A ;
Hartung, T .
BLOOD, 2000, 95 (01) :270-276
[7]  
BRECHER G, 1953, P SOC EXP BIOL MED, V84, P54
[8]  
CARULLI G, 1995, HAEMATOLOGICA, V80, P150
[9]   Effects of in vitro and in vivo cytokine treatment, leucapheresis and irradiation on the function of human neutrophils: Implications for white blood cell transfusion therapy [J].
Cohen, DM ;
Bhalla, SC ;
Anaissie, EJ ;
Hester, JP ;
Savary, CA ;
Rex, JH .
CLINICAL AND LABORATORY HAEMATOLOGY, 1997, 19 (01) :39-47
[10]  
COLOTTA F, 1993, BLOOD, V82, P2258