Understanding the development and function of T follicular helper cells

被引：85

作者：

Nurieva, Roza I. ^{[1
]}

Chung, Yeonseok ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA

来源：

CELLULAR & MOLECULAR IMMUNOLOGY | 2010年 / 7卷 / 03期

基金：

美国国家卫生研究院;

关键词：

autoimmunity; Bcl6; costimulation; IL-21; T follicular helper (Tfh) cells; INTERFERON-REGULATORY FACTOR-4; SYSTEMIC-LUPUS-ERYTHEMATOSUS; GERMINAL-CENTER FORMATION; CXC CHEMOKINE RECEPTOR-5; GENE-EXPRESSION PROGRAM; DEVELOPING TH1 CELLS; I INTERFERON; TRANSCRIPTION FACTOR; HUMORAL IMMUNITY; C-MAF;

D O I：

10.1038/cmi.2010.24

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

A fundamental function of T helper (Th) cells is to regulate B-cell proliferation and immunoglobulin class switching, especially in the germinal centers. Th1 and Th2 lineages of CD4(+) T cells have long been considered to play an essential role in helping B cells by promoting the production immunoglobulin G2a (IgG2a) and IgG1/IgE, respectively. Recently, it has become clear that a subset CD4(+) T cells, named T follicular helper (Tfh) cells, is critical to B-cell response induction. In this review, we summarize the latest advances in our understanding of the regulation of Tfh cell differentiation, the relationship of Tfh cells to other CD4(+) T-cell lineages, and the role of Tfh cells in health and disease. Cellular & Molecular Immunology (2010) 7, 190-197; doi:10.1038/cmi.2010.24; published online 12 April 2010

引用

页码：190 / 197

页数：8

共 98 条

[1]

T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells [J].

Afkarian, M ;

Sedy, JR ;

Yang, J ;

Jacobson, NG ;

Cereb, N ;

Yang, SY ;

Murphy, TL ;

Murphy, KM .

NATURE IMMUNOLOGY, 2002, 3 (06) :549-557

[2]

The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo [J].

Akiba, H ;

Takeda, K ;

Kojima, Y ;

Usui, Y ;

Harada, N ;

Yamazaki, T ;

Ma, J ;

Tezuka, K ;

Yagita, H ;

Okumura, K .

JOURNAL OF IMMUNOLOGY, 2005, 175 (04) :2340-2348

[3]

The germinal center response is impaired in the absence of T cell-expressed CXCR5 [J].

Arnold, Carrie N. ;

Campbell, Daniel J. ;

Lipp, Martin ;

Butcher, Eugene C. .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2007, 37 (01) :100-109

[4]

The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells [J].

Bauquet, Aurelie T. ;

Jin, Hulin ;

Paterson, Alison M. ;

Mitsdoerffer, Meike ;

Ho, I-Cheng ;

Sharpe, Arlene H. ;

Kuchroo, Vijay K. .

NATURE IMMUNOLOGY, 2009, 10 (02) :167-175

[5]

Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies [J].

Bengtsson, AA ;

Sturfelt, G ;

Truedsson, L ;

Blomberg, J ;

Alm, G ;

Vallin, H ;

Rönnblom, L .

LUPUS, 2000, 9 (09) :664-671

[6]

ICOS deficiency is associated with a severe reduction of CXCR5+ CD4 germinal center Th cells [J].

Bossaller, Lukas ;

Burger, Jan ;

Draeger, Ruth ;

Grimbacher, Bodo ;

Knoth, Rolf ;

Plebani, Alessandro ;

Durandy, Anne ;

Baumann, Ulrich ;

Schlesier, Michael ;

Welcher, Andrew A. ;

Peter, Hans Hartmut ;

Warnatz, Klaus .

JOURNAL OF IMMUNOLOGY, 2006, 177 (07) :4927-4932

[7]

Type I Interferon controls the onset and severity of autoimmune manifestations in lpr mice [J].

Braun, D ;

Geraldes, P ;

Demengeot, J .

JOURNAL OF AUTOIMMUNITY, 2003, 20 (01) :15-25

[8]

Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production [J].

Breitfeld, D ;

Ohl, L ;

Kremmer, E ;

Ellwart, J ;

Sallusto, F ;

Lipp, M ;

Förster, R .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (11) :1545-1551

[9]

Brocker T, 1999, EUR J IMMUNOL, V29, P1610, DOI 10.1002/(SICI)1521-4141(199905)29:05<1610::AID-IMMU1610>3.0.CO

[10]

2-8

← 1 2 3 4 5 6 7 8 9 10 →