Representation of the temporal order of visual objects in the primate lateral prefrontal cortex

被引:91
作者
Ninokura, Y
Mushiake, H
Tanji, J [1 ]
机构
[1] Tohoku Univ, Sch Med, Dept Physiol, Sendai, Miyagi 980, Japan
[2] Japan Sci & Technol Corp, Core Res Evolut Sci & Technol, Kawaguchi 3320012, Japan
关键词
D O I
10.1152/jn.00647.2002
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Recollecting a past episode involves remembering the temporal order of events. We studied cellular activity in the lateral prefrontal cortex (PFC) of two monkeys that were required to remember the temporal order in which visual objects appeared and to reach for each object in the same order after a delay. Here, we report the cellular activity in the lateral PFC, focusing on the delay period. We found that 43% of the delay-period activity was selective for the sequence in which the visual objects were presented during the cue period. While the majority of cellular activity was selective for multiple sequences, some cells (31%) were selective for only one of six sequences. Our findings show that PFC cells are involved in holding temporal order information when that information is necessary for planning forthcoming motor behavior.
引用
收藏
页码:2868 / 2873
页数:6
相关论文
共 23 条
[1]   Task-specific neural activity in the primate prefrontal cortex [J].
Asaad, WF ;
Rainer, G ;
Miller, EK .
JOURNAL OF NEUROPHYSIOLOGY, 2000, 84 (01) :451-459
[2]  
BARONE P, 1989, EXP BRAIN RES, V78, P447
[3]   Brain regions differentially involved in remembering what and when: a PET study [J].
Cabeza, R ;
Mangels, J ;
Nyberg, L ;
Habib, R ;
Houle, S ;
McIntosh, AR ;
Tulving, E .
NEURON, 1997, 19 (04) :863-870
[4]   Categorical representation of visual stimuli in the primate prefrontal cortex [J].
Freedman, DJ ;
Riesenhuber, M ;
Poggio, T ;
Miller, EK .
SCIENCE, 2001, 291 (5502) :312-316
[5]   NEURON ACTIVITY RELATED TO SHORT-TERM MEMORY [J].
FUSTER, JM ;
ALEXANDER, GE .
SCIENCE, 1971, 173 (3997) :652-+
[6]  
GOLDMANRAKIC PS, 1987, HDB PHYSL NERVOUS SY, V5, P313
[7]   Task-dependent selectivity of movement-related neuronal activity in the primate prefrontal cortex [J].
Hoshi, E ;
Shima, K ;
Tanji, J .
JOURNAL OF NEUROPHYSIOLOGY, 1998, 80 (06) :3392-3397
[8]   Neuronal activity in the primate prefrontal cortex in the process of motor selection based on two behavioral rules [J].
Hoshi, E ;
Shima, K ;
Tanji, J .
JOURNAL OF NEUROPHYSIOLOGY, 2000, 83 (04) :2355-2373
[9]   THE FRONTAL-CORTEX AND MEMORY FOR TEMPORAL-ORDER [J].
MCANDREWS, MP ;
MILNER, B .
NEUROPSYCHOLOGIA, 1991, 29 (09) :849-859
[10]  
Miller EK, 1996, J NEUROSCI, V16, P5154