Cigarette smoking causes impairment of spermatozoal quality: Andrological and biochemical evaluation

被引:11
作者
Omu, AE [1 ]
Dashti, H [1 ]
Mohammed, AT [1 ]
Mattappallil, AB [1 ]
机构
[1] Kuwait Univ, Fac Med, Dept Obstet & Gynaecol, Safat 13110, Kuwait
关键词
cigarette smoking; spermatozoal quality; impairment;
D O I
10.1159/000026021
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The effect of cigarette smoking on spermatozoal parameters was studied in 40 known cigarette smokers and 40 non-smokers by evaluating sperm parameters, semen and serum levels of cadmium, zinc, copper, selenium and magnesium, circulating antisperm antibodies, and FSH, LH, prolactin and testosterone. Non-smokers and light smokers had better sperm parameters than heavy smokers as indicated by the sperm count (p < 0.03), active motility (p = 0.03), asthenozoospermia (p < 0.05), and positive hypo-osmotic swelling (p < 0.05) tests. The number of smokers with higher titres of circulating antisperm antibodies was larger than that of non-smokers (greater than or equal to 1:128; p < 0.01). Serum testosterone level was higher in non-smokers (18.4 +/- 2.1 pmol/l) than in smokers (14.3 +/- 2.5 pmol/l; p < 0.05). Cadmium levels were higher in the semen and serum of smokers (p < 0.05) when compared to non-smokers (p = 0.05). Cigarette smoking impairs fertility through the putative effect of cadmium in causing testicular endothelial injury and production of antisperm antibodies.
引用
收藏
页码:47 / 53
页数:7
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