Molecular synchronization waves in arrays of allosterically regulated enzymes

被引：11

作者：

Casagrande, Vanessa

Togashi, Yuichi

Mikhailov, Alexander S.

机构：

[1] Hahn Meitner Inst Berlin GmbH, D-14109 Berlin, Germany

[2] Max Planck Gesell, Fritz Haber Inst, D-14195 Berlin, Germany

来源：

PHYSICAL REVIEW LETTERS | 2007年 / 99卷 / 04期

关键词：

D O I：

10.1103/PhysRevLett.99.048301

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

Spatiotemporal pattern formation in a product-activated enzymic reaction at high enzyme concentrations is investigated. Stochastic simulations show that catalytic turnover cycles of individual enzymes can become coherent and that complex wave patterns of molecular synchronization can develop. The analysis based on the mean-field approximation indicates that the observed patterns result from the presence of Hopf and wave bifurcations in the considered system.

引用

页数：4

共 21 条

[1]

Blumenfeld LA., 1994, BIOPHYSICAL THERMODY, DOI [10.1007/978-1-4612-2630-7, DOI 10.1007/978-1-4612-2630-7]

[2]

Casagrande V, 2006, SYNCHRONIZATION WAVE

[3] Internal states of active inclusions and the dynamics of an active membrane [J].