Isolation and propagation of human papillomavirus type 16 in human xenografts implanted in the severe combined immunodeficiency mouse

被引：41

作者：

Bonnez, W

Darin, C

Borkhuis, C

Jensen, KM

Reichman, RC

Rose, RC

机构：

[1] Univ Rochester, Med Ctr, Infect Dis Unit, Sch Med & Dent,Dept Med, Rochester, NY 14642 USA

[2] Univ Rochester, Med Ctr, Infect Dis Unit, Sch Med & Dent,Dept Pathol, Rochester, NY 14642 USA

来源：

JOURNAL OF VIROLOGY | 1998年 / 72卷 / 06期

关键词：

D O I：

10.1128/JVI.72.6.5256-5261.1998

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report the isolation and propagation of human papillomavirus type 16, the main agent of cervical cancer, using human foreskin fragments implanted in severe combined immunodeficiency mice. The infection produced viral particles, and with each passage of the virus it caused lesions identical to intraepithelial neoplasia, the precursor to carcinoma.

引用

页码：5256 / 5261

页数：6

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