Coexistence of systemic lupus erythematosus, tuberous sclerosis and aggressive natural killer-cell leukaemia: coincidence or correlated?

被引：17

作者：

Bekkink, M. Olde ^{[1
]}

Ahmed-Ousenkova, Y. M. ^{[2
]}

Netea, M. G. ^{[1
,3
]}

van der Velden, W. J. ^{[4
]}

Berden, J. H. ^{[2
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, NL-6500 HB Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, Dept Nephrol, NL-6500 HB Nijmegen, Netherlands

[3] Radboud Univ Nijmegen, Med Ctr, Radboud Ctr Infect Dis, NL-6500 HB Nijmegen, Netherlands

[4] Radboud Univ Nijmegen, Med Ctr, Dept Haematol, NL-6500 HB Nijmegen, Netherlands

来源：

LUPUS | 2016年 / 25卷 / 07期

关键词：

Haematological changes; nephritis; systemic lupus erythematosus; tuberous sclerosis; EPSTEIN-BARR-VIRUS; GRANULAR LYMPHOCYTE LEUKEMIA; EPIDEMIOLOGY; RISK; NEOPLASMS; PATHWAYS; GROWTH; CANCER;

D O I：

10.1177/0961203316636466

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Among patients with systemic lupus erythematosus (SLE) there is an increased risk of haematological malignancies, especially non-Hodgkin lymphoma. However, the association of SLE with aggressive CD3 negative natural killer (NK)-cell leukaemia has not been reported so far. We present a case of a 39-year-old woman with SLE, aggressive NK-cell leukaemia and tuberous sclerosis complex. The prior probability of developing the combination of these three rare diseases by coincidence is extremely low (<10(-13)). Possible underlying immunological, genetic and toxic/environmental pathways are discussed.

引用

页码：766 / 771

页数：6

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