A Systems Approach towards an Intelligent and Self-Controlling Platform for Integrated Continuous Reaction Sequences

被引：122

作者：

Ingham, Richard J. ^{[1
]}

Battilocchio, Claudio ^{[1
]}

Fitzpatrick, Daniel E. ^{[1
]}

Sliwinski, Eric ^{[1
]}

Hawkins, Joel M. ^{[2
]}

Ley, Steven V. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[2] Pfizer Worldwide, Res & Dev, Groton, CT 06340 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 01期

基金：

英国工程与自然科学研究理事会;

关键词：

continuous processing; flow reactors; integrated systems; synthetic methods; CONTINUOUS-FLOW SYNTHESIS; MULTISTEP SYNTHESIS; ORGANIC-SYNTHESIS; IR ANALYSIS; PURIFICATION; EXTRACTION; REACTORS; TECHNOLOGY; CHEMISTRY;

D O I：

10.1002/anie.201409356

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Performing reactions in flow can offer major advantages over batch methods. However, laboratory flow chemistry processes are currently often limited to single steps or short sequences due to the complexity involved with operating a multi-step process. Using new modular components for downstream processing, coupled with control technologies, more advanced multi-step flow sequences can be realized. These tools are applied to the synthesis of 2-aminoadamantane-2-carboxylic acid. A system comprising three chemistry steps and three workup steps was developed, having sufficient autonomy and self-regulation to be managed by a single operator.

引用

页码：144 / 148

页数：5

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