Preventing venous thromboembolism in long-term care residents: Cautious advice based on limited data

被引：11

作者：

Pal, Menaka ^{[1
,2
]}

Douketis, James D. ^{[1
,2
]}

机构：

[1] St Josephs Healthcare, Hamilton, ON L8N 4A6, Canada

[2] McMaster Univ, Dept Med, Hamilton, ON, Canada

来源：

CLEVELAND CLINIC JOURNAL OF MEDICINE | 2010年 / 77卷 / 02期

关键词：

HOSPITALIZED MEDICAL PATIENTS; DEEP-VEIN THROMBOSIS; HEPARIN-INDUCED THROMBOCYTOPENIA; ANTICOAGULANT PROPHYLAXIS; PULMONARY-EMBOLISM; RISK-FACTORS; METAANALYSIS; MULTICENTER; THROMBOPROPHYLAXIS; MANAGEMENT;

D O I：

10.3949/ccjm.77a.09096

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In hospitalized medical patients, randomized trials have established that anticoagulant prophylaxis has an acceptable benefit-to-risk ratio: ie, it lowers the incidence of clinically silent and symptomatic venous thromboembolism (VTE), including fatal pulmonary embolism, more than it raises the risks of bleeding and other complications. However, no similar trials have been done in long-term care residents. More research is needed to ascertain which long-term care residents would benefit most from VTE prophylaxis. In the absence of evidence-based guidelines, we advocate a selective approach.

引用

页码：123 / 130

页数：8

共 27 条

[1]

Bounameaux H, 1999, THROMB HAEMOSTASIS, V82, P931

[2] Venous thromboembolism risk and prophylaxis in the acute hospital care setting (ENDORSE study): a multinational cross-sectional study [J].

Cohen, Alexander T. ;

Tapson, Victor F. ;

Bergmann, Jean-Francois ;

Goldhaber, Samuel Z. ;

Kakkar, Ajay K. ;

Deslandes, Bruno ;

Huang, Wei ;

Zayaruzny, Maksim ;

Emery, Leigh ;

Anderson, Frederick A., Jr. .

LANCET, 2008, 371 (9610) :387-394

[3] Questions for societies with ''third age'' populations [J].

Cornman, JM ;

Achenbaum, WA ;

Cassel, CK ;

Cohen, GD ;

Cole, TR ;

Fahey, C ;

Friedland, RB ;

Harootyan, LK ;

Hayflick, L ;

Holstein, MB ;

Moody, HR ;

Wetle, TT ;

Schutz, CA .

ACADEMIC MEDICINE, 1997, 72 (10) :856-862

[4] Effectiveness of thigh-length graduated compression stockings to reduce the risk of deep vein thrombosis after stroke (CLOTS trial 1): a multicentre, randomised controlled trial [J].

Dennis, M. ;

Cranswick, G. ;

Deary, A. ;

Fraser, A. ;

Graham, C. ;

Grant, S. ;

Gunkel, A. ;

Hunter, J. ;

MacRae, A. ;

Perry, D. ;

Soosay, V. ;

Williams, C. ;

Williamson, A. ;

Young, A. ;

Dennis, M. ;

Sandercock, P. A. G. ;

Reid, J. ;

Graham, C. ;

Murray, G. ;

Venables, G. ;

Rudd, A. ;

Bowler, G. ;

Cranswick, G. ;

Lewis, S. ;

Rudd, A. ;

Sandercock, P. A. G. ;

Celani, M. G. ;

Ricci, S. ;

Lindley, R. ;

Hautvast, M. ;

Paterson, M. ;

Reid, J. ;

Ting, T. ;

Baigent, C. ;

Bamford, J. ;

Slattery, J. .

LANCET, 2009, 373 (9679) :1958-1965

[5] Meta-analysis: Anticoagulant prophylaxis to prevent symptomatic venous thromboembolism in hospitalized medical patients [J].

Dentali, Francesco ;

Douketis, James D. ;

Gianni, Monica ;

Lim, Wendy ;

Crowther, Mark A. .

ANNALS OF INTERNAL MEDICINE, 2007, 146 (04) :278-288

[6] Prophylaxis against deep vein thrombosis in critically ill patients with severe renal insufficiency with the low-molecular-weight heparin dalteparin -: An assessment of safety and pharmacodynamics:: The DIRECT study [J].

Douketis, James ;

Cook, Deborah ;

Meade, Maureen ;

Guyatt, Gordon ;

Geerts, William ;

Skrobik, Yoanna ;

Albert, Martin ;

Granton, John ;

Hebert, Paul ;

Pagliarello, Guiseppe ;

Marshall, John ;

Fowler, Robert ;

Freitag, Andreas ;

Rabbat, Christian ;

Anderson, David ;

Zytaruk, Nicole ;

Heels-Ansdell, Diane ;

Crowther, Mark .

ARCHIVES OF INTERNAL MEDICINE, 2008, 168 (16) :1805-1812

[7] Prevention of venous thromboembolism in hospitalized medical patients: addressing some practical questions [J].

Douketis, James D. .

CURRENT OPINION IN PULMONARY MEDICINE, 2008, 14 (05) :381-388

[8] Comparison of bleeding in patients with nonvalvular atrial fibrillation treated with ximelagatran or warfarin - Assessment of incidence, case-fatality rate, time course and sites of bleeding, and risk factors for bleeding [J].

Douketis, JD ;

Arneklev, K ;

Goldhaber, SZ ;

Spandorfer, J ;

Halperin, F ;

Horrow, J .

ARCHIVES OF INTERNAL MEDICINE, 2006, 166 (08) :853-859

[9] Prophylaxis for thromboembolism in hospitalized medical patients [J].

Francis, Charles W. .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (14) :1438-1444

[10] Prevention of venous thromboembolism [J].

Geerts, William H. ;

Bergqvist, David ;

Pineo, Graham F. ;

Heit, John A. ;

Samama, Charles M. ;

Lassen, Michael R. ;

Colwell, Clifford W. .

CHEST, 2008, 133 (06) :381S-453S

← 1 2 3 →