Shifting HIFs in osteoarthritis

被引：88

作者：

Husa, Matthew ^{[1
]}

Liu-Bryan, Ru

Terkeltaub, Robert

机构：

[1] Vet Affairs Med Ctr, San Diego, CA 92161 USA

来源：

NATURE MEDICINE | 2010年 / 16卷 / 06期

关键词：

CHONDROCYTE HYPERTROPHY; DIFFERENTIATION; INDUCTION; RESPONSES; ADAMTS-5; REPAIR;

D O I：

10.1038/nm0610-641

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

There is no cure for osteoarthritis-the most common disease of the joints. By piecing together the molecular events that drive the progression of this debilitating disease, recent studies published in Nature Medicine put hypoxia-inducible factor-2 alpha (HIF-2 alpha) in the driver's seat, opening up new avenues for early detection and treatment (pages 678-686 and 687-693).

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收藏

页码：641 / 644

页数：5

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