8-OHdG in Cerebrospinal Fluid as a Marker of Oxidative Stress in Various Neurodegenerative Diseases

被引：61

作者：

Gmitterova, K. ^{[2
]}

Heinemann, U.

Gawinecka, J.

Varges, D.

Ciesielczyk, B.

Valkovic, P. ^{[2
]}

Benetin, J. ^{[2
]}

Zerr, I. ^{[1
]}

机构：

[1] Univ Gottingen, Dept Neurol, Univ Med Sch, DE-37075 Gottingen, Germany

[2] Comenius Univ, Dept Neurol 2, Bratislava, Slovakia

来源：

NEURODEGENERATIVE DISEASES | 2009年 / 6卷 / 5-6期

关键词：

Cerebrospinal fluid; 8-OHdG; Parkinson's disease; Oxidative stress; PARKINSONS-DISEASE; MITOCHONDRIAL-DNA; ALZHEIMER-DISEASE; PROMINENT FEATURE; RNA OXIDATION; DAMAGE; DEMENTIA; 8-HYDROXYGUANINE; LYMPHOCYTES; DYSFUNCTION;

D O I：

10.1159/000237221

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: The 8-hydroxy-2 deoxyguanosine (8-OHdG) is a product of nucleoside oxidation of DNA and a reliable marker of oxidative stress markers. Increased levels of oxidative stress have been reported in the cerebrospinal fluid (CSF) of patients with various neurodegenerative disorders. Objective: In search of a biochemical indicator of Parkinson's disease (PD), we analyzed the levels 8-OHdG in the CSF of 99 patients, using ELISA to assess the differences between various neurodegenerative disorders. Results: Statistically significant higher CSF levels (p = 0.022) of 8-OHdG in non-demented PD patients as compared to the control group were observed. No differences between CSF 8-OHdG levels and age at the time of lumbar puncture, presence or severity of dementia, or gender were found. Conclusions: 8-OHdG levels could be potentially useful in the neurochemically supported diagnosis of PD. Copyright (C) 2009 S. Karger AG, Basel

引用

页码：263 / 269

页数：7

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