Mediators of inflammation

被引:80
作者
Sacca, R
Cuff, CA
Ruddle, NH
机构
[1] Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06520 USA
[2] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
关键词
D O I
10.1016/S0952-7915(97)80189-6
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Therapeutic studies and genetically engineered animals have elucidated the inflammatory roles of cytokines and chemokines in autoimmune disease. Most unexpected has been a continuum of recent evidence demonstrating that inflammatory mediators are crucial in lymphoid organ development, thus suggesting that these hitherto unrelated processes have common elements with implications for determinant spreading.
引用
收藏
页码:851 / 857
页数:7
相关论文
共 58 条
[1]   p55 tumor necrosis factor receptor fusion protein in the treatment of patients with severe sepsis and septic shock - A randomized controlled multicenter trial [J].
Abraham, E ;
Glauser, MP ;
Butler, T ;
Garbino, J ;
Gelmont, D ;
Laterre, PF ;
Kudsk, K ;
Bruining, HA ;
Otto, C ;
Tobin, E ;
Zwingelstein, C ;
Lesslauer, W ;
Leighton, A .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 277 (19) :1531-1538
[2]   Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice [J].
Alimzhanov, MB ;
Kuprash, DV ;
KoscoVilbois, MH ;
Luz, A ;
Turetskaya, RL ;
Tarakhovsky, A ;
Rajewsky, K ;
Nedospasov, SA ;
Pfeffer, K .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (17) :9302-9307
[3]  
BANKS TA, 1995, J IMMUNOL, V155, P1685
[4]   INFLAMMATORY CYTOKINES WITHIN THE CENTRAL-NERVOUS-SYSTEM - SOURCES, FUNCTION, AND MECHANISM OF ACTION [J].
BENVENISTE, EN .
AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 263 (01) :C1-C16
[5]  
Berman JW, 1996, J IMMUNOL, V156, P3017
[6]  
Chensue SW, 1996, J IMMUNOL, V157, P4602
[7]   Germinal center formation and local immunoglobulin E (IgE) production in the lung after an airway antigenic challenge [J].
Chvatchko, Y ;
KoscoVilbois, MH ;
Herren, S ;
Lefort, J ;
Bonnefoy, JY .
JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (06) :2353-2360
[8]   INTERSEPT: An international, multicenter, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis [J].
Cohen, J ;
Carlet, J .
CRITICAL CARE MEDICINE, 1996, 24 (09) :1431-1440
[9]   Chronic tumor necrosis factor alters T cell responses by attenuating T cell receptor signaling [J].
Cope, AP ;
Liblau, RS ;
Yang, XD ;
Congia, M ;
Laudanna, C ;
Schreiber, RD ;
Probert, L ;
Kollias, G ;
McDevitt, HO .
JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (09) :1573-1584
[10]   Abnormal Development of Peripheral Lymphoid Organs in Mice Deficient in Lymphotoxin [J].
De Togni, Pietro ;
Goellner, Josphe ;
Ruddle, Nancy H. ;
Streeter, Philip R. ;
Fick, Andrea ;
Mariathasan, Sanjeev ;
Smith, Stacy C. ;
Carison, Rebecca ;
Shonnick, Laurie P. ;
strauss-Schoenberger, Jena ;
Russell, John H. ;
Karr, Robert ;
Chaplin, David D. .
JOURNAL OF IMMUNOLOGY, 2014, 192 (05) :2010-2014