Mechanisms and Consequences of Macromolecular Phase Separation

被引：268

作者：

Bergeron-Sandoval, Louis-Philippe ^{[1
]}

Safaee, Nozhat ^{[1
]}

Michnick, Stephen W. ^{[1
,2
]}

机构：

[1] Univ Montreal, Dept Biochim, CP 6128,Succursale Ctr Ville, Montreal, PQ H3C 3J7, Canada

[2] Univ Montreal, Ctr Robert Cedergren, Bioinformat & Genom, CP 6128,Succursale Ctr Ville, Montreal, PQ H3C 3J7, Canada

来源：

CELL | 2016年 / 165卷 / 05期

关键词：

INTRINSICALLY DISORDERED PROTEINS; CELL-FREE FORMATION; NEURONAL ISOFORM; POLYMER PHYSICS; LIQUID DROPLETS; P GRANULES; RNA; PRION; POLYGLUTAMINE; AGGREGATION;

D O I：

10.1016/j.cell.2016.05.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Over a century ago, colloidal phase separation of matter into non-membranous bodies was recognized as a fundamental organizing principal of cell ''protoplasm.'' Recent insights into the molecular properties of such phase-separated bodies present challenges to our understanding of cellular protein interaction networks, as well as opportunities for interpreting and understanding of native and pathological genetic and molecular interactions. Here, we briefly review examples of and discuss physical principles of phase-separated cellular bodies and then reflect on how knowledge of these principles may direct future research on their functions.

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收藏

页码：1067 / 1079

页数：13

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