Selective elimination of mitochondria from living cells induced by inhibitors of bioenergetic functions

被引：33

作者：

Lyamzaev, KG ^{[1
]}

Pletjushkina, OY ^{[1
]}

Saprunova, VB ^{[1
]}

Bakeeva, LE ^{[1
]}

Chernyak, BV ^{[1
]}

Skulachev, VP ^{[1
]}

机构：

[1] Moscow MV Lomonosov State Univ, AN Belozersky Inst Physicochem Biol, Moscow 119899, Russia

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2004年 / 32卷

关键词：

elimination of mitochondria; fission; fusion; mitochondrial inhibitors; reactive oxygen species (ROS);

D O I：

10.1042/BST0321070

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The inhibitors of oxidative phosphorylation induced fragmentation of mitochondria without any signs of apoptosis in CV-1 and HeLa cells. Prolonged treatment with the uncouplers (alone or in combination with the inhibitors of respiration) caused perinuclear clusterization of mitochondria, followed by their selective elimination. The fraction of mitochondria-depleted cells remained viable.

引用

页码：1070 / 1071

页数：2

共 13 条

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