A novel ketone synthesis by a palladium-catalyzed reaction of thiol esters and organozinc reagents

被引：288

作者：

Tokuyama, H ^{[1
]}

Yokoshima, S ^{[1
]}

Yamashita, T ^{[1
]}

Fukuyama, T ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, CREST, Japan Sci & Technol Corp,Bunkyo Ku, Tokyo 113, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 20期

关键词：

D O I：

10.1016/S0040-4039(98)00456-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A variety of ketones have been prepared by a palladium-catalyzed reaction of ethanethiol esters with organozinc reagents. Various functional groups, including esters, ketones, aromatic halides and aldehydes, tolerate the reaction conditions. The reaction can also be applied to the synthesis of oc-amino ketones using the corresponding L-alpha-amino thiol esters without racemization. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3189 / 3192

页数：4

共 24 条

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