Cyclic nucleotide gated channels as regulators of CNS development and plasticity

被引：96

作者：

Zufall, F ^{[1
]}

Shepherd, GM ^{[1
]}

Barnstable, CJ ^{[1
]}

机构：

[1] YALE UNIV, SCH MED, DEPT OPHTHALMOL & VISUAL SCI, NEW HAVEN, CT 06510 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 1997年 / 7卷 / 03期

关键词：

D O I：

10.1016/S0959-4388(97)80070-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cyclic nucleotide gated (CNG) cation channels are critical for signal transduction in vertebrate visual and olfactory systems. Members of the CNG channel gene family have now been cloned from a number of species, from Caenorhabditis elegans to humans. An important advance has been the discovery that CNG channels are present in many neurons of the mammalian brain. CNG channels act as molecular links between G-protein-coupled cascades, Ca2+-signalling systems, and gaseous messenger pathways. Perhaps most striking are recent data implicating CNG channels in both developmental and synaptic plasticity.

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页码：404 / 412

页数：9

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