DNA repair: PARP - another guardian angel?

被引：160

作者：

Jeggo, PA ^{[1
]}

机构：

[1] Univ Sussex, MRC, Cell Mutat Unit, Brighton BN1 9RR, E Sussex, England

来源：

CURRENT BIOLOGY | 1998年 / 8卷 / 02期

关键词：

D O I：

10.1016/S0960-9822(98)70032-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cell lines and mice defective in poly(ADP-ribose) polymerase (PARP) have elevated spontaneous genetic rearrangements and abnormal responses to stresses. These results may be explained by an altered response to damage induced by free radicals, and suggest that PARP limits genomic instability from such damage.

引用

页码：R49 / R51

页数：3

共 20 条

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