Nerve conduction study of the association between glycemic variability and diabetes neuropathy

被引：56

作者：

Akaza, Miho ^{[1
]}

Akaza, Itaru ^{[2
]}

Kanouchi, Tadashi ^{[3
]}

Sasano, Tetsuo ^{[4
]}

Sumi, Yuki ^{[1
]}

Yokota, Takanori ^{[5
]}

机构：

[1] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Resp & Nervous Syst Sci, Biomed Lab Sci,Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138519, Japan

[2] Shuuwa Gen Hosp, Internal Med Endocrinol & Metab, 1200 Yaharashinden, Kasukabe, Saitama, Japan

[3] Tokyo Med & Dent Univ, Clin Lab, Med Hosp, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138519, Japan

[4] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Biomed Lab Sci, Cardiovasc Physiol,Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138519, Japan

[5] Tokyo Med & Dent Univ, Dept Neurol & Neurol Sci, Grad Sch, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138519, Japan

来源：

DIABETOLOGY & METABOLIC SYNDROME | 2018年 / 10卷

基金：

日本学术振兴会;

关键词：

Glycemic variability; Continuous glucose monitoring; Diabetes peripheral neuropathy; Nerve conduction study; CARDIOVASCULAR AUTONOMIC NEUROPATHY; PERIPHERAL NEUROPATHY; GLUCOSE VARIABILITY; OXIDATIVE STRESS; RISK-FACTOR; RETINOPATHY; COMPLICATIONS; EXCURSIONS; PREVALENCE; ACTIVATION;

D O I：

10.1186/s13098-018-0371-0

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Background: It remains unclear whether glycemic variability is related to diabetes microvascular disease, especially diabetes peripheral neuropathy (DPN). We investigated the association between glycemic variability and DPN with type 1 or 2 diabetes. Methods: Forty patients (23 males and 17 females; aged 34-79 years) underwent continuous glucose monitoring (CGM) and a nerve conduction study (NCS). Glycemic variability was estimated by mean amplitude of glycemic excursions (MAGE) in CGM. DPN was quantitatively evaluated by NCS in the median, tibial, sural and medial plantar nerves. Results: MAGE had a significantly positive correlation with disease duration and low-density lipoprotein cholesterol level (r = 0.462, p = 0.003; and r = 0.40, p = 0.011, respectively), and a significantly negative correlation with BMI and medial plantar compound nerve action potential amplitude (r = -0.39, p = 0.012; and r = -0.32, p = 0.042, respectively). Multivariate linear regression analysis with adjustment for clinical background showed that MAGE (beta = -0.49, p = 0.007) was independently associated with a higher risk of medial plantar neuropathy. Conclusions: Glycemic variability may be an independent risk factor for DPN.

引用

页数：8

共 35 条

[1]

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[2]

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