Developmental exposure to endocrine disruptors and the obesity epidemic

被引:175
作者
Newbold, Retha R.
Padilla-Banks, Elizabeth
Snyder, Ryan J.
Phillips, Terry M.
Jefferson, Wendy N.
机构
[1] NIEHS, Dev Endocrinol & Endocrine Disruptor Sect, Sect Lab Mol Toxicol, NIH,DHHS, Res Triangle Pk, NC 27709 USA
[2] DHHS, Div Bioengn & Phys Sci, Off Res Serv, Off Director,NIH, Bethesda, MD 20892 USA
关键词
fetal exposure; neonatal exposure; overweight; obese; adipocytes; obesogens; diabetes; cardiovascular disease; epigenetic; DOHaD;
D O I
10.1016/j.reprotox.2006.12.010
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Xenobiotic and dietary compounds with hormone-like activity can disrupt endocrine signaling pathways that play important roles during perinatal differentiation and result in alterations that are not apparent until later in life. Evidence implicates developmental exposure to environmental hormone-mimics with a growing list of health problems. Obesity is currently receiving needed attention since it has potential to overwhelm health systems worldwide with associated illnesses such as diabetes and cardiovascular disease. Here, we review the literature that proposes an association of exposure to environmental endocrine disrupting chemicals with the development of obesity. We describe an animal model of developmental exposure to diethylstilbestrol (DES), a potent perinatal endocrine disruptor with estrogenic activity, to study mechanisms involved in programming an organism for obesity. This experimental animal model provides an example of the growing scientific field termed "the developmental origins of adult disease" and suggests new targets of abnormal programming by endocrine disrupting chemicals. Published by Elsevier Inc.
引用
收藏
页码:290 / 296
页数:7
相关论文
共 31 条
[1]   Chemical toxins: A hypothesis to explain the global obesity epidemic [J].
Baillie-Hamilton, PF .
JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE, 2002, 8 (02) :185-192
[2]   Fetal origins of adult disease:: strength of effects and biological basis [J].
Barker, DJP ;
Eriksson, JG ;
Forsén, T ;
Osmond, C .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2002, 31 (06) :1235-1239
[3]  
BERN H, 1992, CHEM INDUCED ALTERAT
[4]   DEVELOPMENTAL EFFECTS OF ENDOCRINE-DISRUPTING CHEMICALS IN WILDLIFE AND HUMANS [J].
COLBORN, T ;
SAAL, FSV ;
SOTO, AM .
ENVIRONMENTAL HEALTH PERSPECTIVES, 1993, 101 (05) :378-384
[5]  
Colborn T., 1992, CHEM INDUCED ALTERAT
[6]  
Colborn T., 1996, OUR STOLEN FUTURE
[7]   Evidence for a role of developmental genes in the origin of obesity and body fat distribution [J].
Gesta, S ;
Blüher, M ;
Yamamoto, Y ;
Norris, AW ;
Berndt, J ;
Kralisch, S ;
Boucher, J ;
Lewis, C ;
Kahn, CR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (17) :6676-6681
[9]   DIETHYLSTILBESTROL REVISITED - A REVIEW OF THE LONG-TERM HEALTH-EFFECTS [J].
GIUSTI, RM ;
IWAMOTO, K ;
HATCH, EE .
ANNALS OF INTERNAL MEDICINE, 1995, 122 (10) :778-788
[10]   Developmental origins of disease paradigm: A mechanistic and evolutionary perspective [J].
Gluckman, PD ;
Hanson, MA .
PEDIATRIC RESEARCH, 2004, 56 (03) :311-317