Identification of a series of highly potent activators of the Nurr1 signaling pathway

被引：35

作者：

Hintermann, Samuel ^{[1
]}

Chiesi, Michele ^{[1
]}

von Krosigk, Ulrike ^{[1
]}

Mathe, Daniele ^{[1
]}

Felber, Richard ^{[1
]}

Hengerer, Bastian ^{[1
]}

机构：

[1] Novartis Inst BioMed Res, Neurosci Res, CH-4002 Basel, Switzerland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 01期

关键词：

Nurr1; activation; Parkinson's disease;

D O I：

10.1016/j.bmcl.2006.09.062

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The nuclear receptor Nurr1 (NR4A2) is critically involved in the development and maintenance of midbrain dopaminergic neurons and is believed to function independently of endogenous activation. The hit identification and SAR studies leading to isoxazolo-pyridinone 7e, a highly potent, brain penetrable activator of the Nurr1 signaling pathway, are described. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：193 / 196

页数：4

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