Clinical Safety and Efficacy of a Novel Thin-Strut Cobalt-Chromium Coronary Stent System: Results of the real world coroflex blue registry

被引:18
作者
Bocksch, Wolfgang [1 ]
Pomar, Francisco [2 ]
Dziarmaga, Mieczyslaw [3 ]
Tresukosol, Damras [4 ]
Ismail, Omar [5 ]
Janek, Bronislav [6 ]
Carlsson, Joerg [7 ]
Simon, Jean-Philippe [8 ]
机构
[1] Charite, Dept Cardiol, D-13353 Berlin, Germany
[2] Hosp Gen Valencia, Dept Cardiol, Valencia, Spain
[3] Szpital Klin Przemienienia Panskiego SPSK Poznan, Dept Cardiol, Poznan, Poland
[4] Siriraj Hosp, Dept Cardiol, Bangkok, Thailand
[5] Penang Gen Hosp, Dept Cardiol, George Town, Malaysia
[6] Klin Kardiol IKEM, Dept Cardiol, Prague, Czech Republic
[7] Cent Hosp Kalmar, Dept Cardiol, Kalmar, Sweden
[8] Clin Louis Pasteur, Dept Cardiol, Esseys Les Nancy, France
关键词
cobalt-chromium stent; percutaneous coronary intervention; angiography-coronary; diagnostic cardiac catheterization; restenosis; PACLITAXEL-ELUTING STENTS; RANDOMIZED CONTROLLED-TRIAL; BARE-METAL STENT; ARTERY-DISEASE; BALLOON ANGIOPLASTY; RESTENOSIS; IMPLANTATION; MULTICENTER; PREVENTION; THROMBOSIS;
D O I
10.1002/ccd.22208
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives: The aim of this registry was to evaluate the clinical efficacy and safety of the Coroflex Blue cobalt-chromium stent in real-world practice. Background: The development of cobalt-chromium bare-metal stents (BMS) with thinner struts has lead to better deliverability and lower target-lesion revascularization rates compared with stainless steel BMS. Methods: The Coroflex Blue Registry was an international, prospective, multicenter registry enrolling patients with symptomatic ischemic heart disease attributable to single de novo or restenotic nonstented lesions of a single vessel amenable for percutaneous stenting. The primary end point was clinically driven target-lesion revascularisation (TLR) 6 months after enrolment, secondary endpoints were technical/procedural success, in-hospital outcome, definite stent thrombosis and major adverse cardiac events (death, myocardial infarction, or TLR) after 6 months. Results: The registry included 2,315 patients (mean age 64.3 +/- 11.1 years, 19.8% diabetes, 37.3% acute myocardial infarction). Although a complex lesion cohort with 60.3% Typ B(2)/C-lesions, the technical success rate was 99.1% and the procedural success rate 98.5%. The incidence of TLR after 6 months was 5.5% and the cumulative 6-month acute/subacute stent thrombosis rate was 1.6%. After 6 months cumulative event-free survival was 90.8% in all patients and 87% in patients with acute PCI for acute myocardial infarction. Conclusions: This registry demonstrates the safety and efficacy of the Coroflex Blue cobalt-chromium stent platform in real-world practice. In the era of drug-eluting stents (DES), these results raise the serious question if the use of DES for primary prevention of restenosis and TLR is really justified. (C) 2009 Wiley-Liss, Inc.
引用
收藏
页码:78 / 85
页数:8
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