Tityustoxin-induced release of ATP from rat brain cortical synaptosomes

被引：4

作者：

Salgado, AHI

Prado, MAM

MoraesSantos, T

RomanoSilva, MA

Gomez, MV

机构：

[1] UFMG,FAC FARM,ICB,DEPT FARMACOL,BR-31270901 BELO HORIZONT,MG,BRAZIL

[2] UFMG,FAC FARM,DEPT FISIOL & BIOFIS,BELO HORIZONT,MG,BRAZIL

[3] UFMG,FAC FARM,DEPT ALIMENTOS,BELO HORIZONT,MG,BRAZIL

来源：

NEUROSCIENCE LETTERS | 1997年 / 229卷 / 02期

关键词：

ATP release; tityustoxin; tetrodotoxin; synaptosomes;

D O I：

10.1016/S0304-3940(97)00436-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Tityustoxin, a scorpion toxin that alters the Na+ channel activity, induces release of ATP from rat brain cortical synaptosomes. The effect of tityustoxin is dependent on its concentration and incubation time. Continuously or cumulative release of ATP evoked by tityustoxin was calcium-dependent and interestingly only partially inhibited by tetrodotoxin. We suggest that tityustoxin mainly releases ATP from the vesicular pool but other pools may also be involved. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：113 / 116

页数：4

共 21 条

[1] EFFECTS OF POTASSIUM, VERATRIDINE AND SCORPION-VENOM ON CALCIUM ACCUMULATION AND TRANSMITTER RELEASE BY NERVE-TERMINALS INVITRO [J].