The role of CD95 in the regulation of peripheral T-cell apoptosis

被引:154
作者
Krueger, A [1 ]
Fas, SC [1 ]
Baumann, S [1 ]
Krammer, PH [1 ]
机构
[1] German Canc Res Ctr, Tumorimmunol Program, D-69120 Heidelberg, Germany
关键词
D O I
10.1034/j.1600-065X.2003.00047.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Apoptosis of activated peripheral T cells during the termination phase of an immune response is critical to maintain T-cell homeostasis. Activated T cells can be removed by two mechanisms: activation-induced cell death (AICD) and death by neglect. AICD is triggered by death receptors, whereas death by neglect is induced by cytokine withdrawal. CD95 (APO-1/Fas) belongs to the subfamily of death receptors and plays a major role in AICD. In this review, we focus on the molecular mechanisms of AICD, in particular those involving the CD95 system. Moreover, we discuss the relative contribution of AICD and death by neglect to terminate a T-cell immune response. In order to become fully activated, T cells require a second signal provided by antigen-presenting cells. We discuss how these costimulatory signals counteract pro-apoptotic signals and, finally, which signals might protect T cells from death to generate a pool of memory T cells.
引用
收藏
页码:58 / 69
页数:12
相关论文
共 147 条
  • [1] ABERRANT TRANSCRIPTION CAUSED BY THE INSERTION OF AN EARLY TRANSPOSABLE ELEMENT IN AN INTRON OF THE FAS ANTIGEN GENE OF LPR MICE
    ADACHI, M
    WATANABEFUKUNAGA, R
    NAGATA, S
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (05) : 1756 - 1760
  • [2] A POSSIBLE ROLE FOR BCL-2 IN REGULATING T-CELL MEMORY - A BALANCING ACT BETWEEN CELL-DEATH AND SURVIVAL
    AKBAR, AN
    SALMON, M
    SAVILL, J
    JANOSSY, G
    [J]. IMMUNOLOGY TODAY, 1993, 14 (11): : 526 - 532
  • [3] FAS LIGAND MEDIATES ACTIVATION-INDUCED CELL-DEATH IN HUMAN T-LYMPHOCYTES
    ALDERSON, MR
    TOUGH, TW
    DAVISSMITH, T
    BRADDY, S
    FALK, B
    SCHOOLEY, KA
    GOODWIN, RG
    SMITH, CA
    RAMSDELL, F
    LYNCH, DH
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (01) : 71 - 77
  • [4] Molecular ordering of the initial signaling events of CD95
    Algeciras-Schimnich, A
    Shen, L
    Barnhart, BC
    Murmann, AE
    Burkhardt, JK
    Peter, ME
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (01) : 207 - 220
  • [5] Algeciras-Schimnich A, 1999, J IMMUNOL, V162, P5205
  • [6] Probing lymphocyte biology by genomic-scale gene expression analysis
    Alizadeh, A
    Eisen, M
    Botstein, D
    Brown, PO
    Staudt, LM
    [J]. JOURNAL OF CLINICAL IMMUNOLOGY, 1998, 18 (06) : 373 - 379
  • [7] Extracellular matrix interacts with soluble CD95L: Retention and enhancement of cytotoxicity
    Aoki, K
    Kurooka, M
    Chen, JJ
    Petryniak, J
    Nabel, EG
    Nabel, GJ
    [J]. NATURE IMMUNOLOGY, 2001, 2 (04) : 333 - 337
  • [8] Estimating the precursor frequency of naive antigen-specific CD8 T cells
    Blattman, JN
    Antia, R
    Sourdive, DJD
    Wang, XC
    Kaech, SM
    Murali-Krishna, K
    Altman, JD
    Ahmed, R
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (05) : 657 - 664
  • [9] TRAIL receptor-2 signals apoptosis through FADD and caspase-8
    Bodmer, JL
    Holler, N
    Reynard, S
    Vinciguerra, P
    Schneider, P
    Juo, P
    Blenis, J
    Tschopp, J
    [J]. NATURE CELL BIOLOGY, 2000, 2 (04) : 241 - 243
  • [10] PROPRIOCIDAL APOPTOSIS OF MATURE T-LYMPHOCYTES OCCURS AT S-PHASE OF THE CELL-CYCLE
    BOEHME, SA
    LENARDO, MJ
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1993, 23 (07) : 1552 - 1560