Immune-mediated alteration in gut physiology and its role in host defence in nematode infection

被引:100
作者
Khan, WI [1 ]
Collins, SM [1 ]
机构
[1] McMaster Univ, Hlth Sci Ctr, Dept Med, Intestinal Dis Res Program, Hamilton, ON L8N 3Z5, Canada
关键词
goblet cells; infection; inflammation; nematode; smooth muscle; Th2 immune response;
D O I
10.1111/j.0141-9838.2004.00715.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Activation of the mucosal immune system of the gastrointestinal tract in nematode infection results in altered intestinal physiology, which includes changes in intestinal motility and mucus production. These changes are considered to be under direct immunological control rather than a non-specific consequence of the inflammatory reaction to the infective agent. However, little is known about the immunological basis for the changes in intestinal physiology accompanying nematode infection, or the precise role of these changes in host defence, which remains an important area to explore. In this review we describe the mechanisms by which the immune response to nematode infection influences the changes in two major cells of intestinal physiology, namely smooth muscle and goblet cells, and how these changes in intestinal physiology contribute to the host defence. Data clearly demonstrate that the T helper (Th) 2 type immune response generated by nematode infection plays an important role in the development of infection-induced intestinal muscle hypercontractility and goblet cell hyperplasia and that these immune-mediated changes in intestinal physiology are associated with worm expulsion. These observations strongly suggest that intestinal muscle contractility, goblet cell hyperplasia and worm expulsion share a common immunological basis and may be causally related. These data not only provide insights into host defence in nematode infection in the context of muscle function and goblet cell response, but also have broad implications in elucidating the pathophysiology of a wide range of gastrointestinal disorders associated with altered gut physiology.
引用
收藏
页码:319 / 326
页数:8
相关论文
共 81 条
[1]   INTRINSIC JEJUNAL PROPULSION IN THE GUINEA-PIG DURING PARASITISM WITH TRICHINELLA-SPIRALIS [J].
ALIZADEH, H ;
CASTRO, GA ;
WEEMS, WA .
GASTROENTEROLOGY, 1987, 93 (04) :784-790
[2]  
Allen A., 1981, PHYSL GASTROINTESTIN, P617
[3]   INVOLVEMENT OF 5-HYDROXYTRYPTAMINE, PROSTAGLANDIN-E2, AND CYCLIC ADENOSINE-MONOPHOSPHATE IN CHOLERA TOXIN-INDUCED FLUID SECRETION IN THE SMALL-INTESTINE OF THE RAT INVIVO [J].
BEUBLER, E ;
KOLLAR, G ;
SARIA, A ;
BUKHAVE, K ;
RASKMADSEN, J .
GASTROENTEROLOGY, 1989, 96 (02) :368-376
[4]   IL-4 and IL-13 up-regulate intestinal trefoil factor expression: Requirement for STAT6 and de novo protein synthesis [J].
Blanchard, C ;
Durual, S ;
Estienne, M ;
Bouzakri, K ;
Heim, MH ;
Blin, N ;
Cuber, JC .
JOURNAL OF IMMUNOLOGY, 2004, 172 (06) :3775-3783
[5]   INFLAMMATION CAUSES HYPERPLASIA AND HYPERTROPHY IN SMOOTH-MUSCLE OF RAT SMALL-INTESTINE [J].
BLENNERHASSETT, MG ;
VIGNJEVIC, P ;
VERMILLION, DL ;
COLLINS, SM .
AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 262 (06) :G1041-G1046
[6]   ALTERATIONS IN HUMAN COLONIC MUCIN OCCURRING WITH CELLULAR-DIFFERENTIATION AND MALIGNANT TRANSFORMATION [J].
BOLAND, CR ;
MONTGOMERY, CK ;
KIM, YS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (06) :2051-2055
[7]   Abnormalities in mucin gene expression in Crohn's disease [J].
Buisine, MP ;
Desreumaux, P ;
Debailleul, V ;
Gambiez, L ;
Geboes, K ;
Ectors, N ;
Delescaut, MP ;
Degand, P ;
Aubert, JP ;
Colombel, JF ;
Porchet, N .
INFLAMMATORY BOWEL DISEASES, 1999, 5 (01) :24-32
[8]   KINETICS OF INTESTINAL LAMINA PROPRIA MAST-CELLS, GLOBULE LEUKOCYTES, INTRAEPITHELIAL LYMPHOCYTES, GOBLET CELLS AND EOSINOPHILS IN MURINE STRONGYLOIDIASIS [J].
CARROLL, SM ;
MAYRHOFER, G ;
DAWKINS, HJS ;
GROVE, DI .
INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1984, 74 (04) :311-317
[9]   LOCALIZATION OF MUCIN (MUC2 AND MUC3) MESSENGER-RNA AND PEPTIDE EXPRESSION IN HUMAN NORMAL INTESTINE AND COLON-CANCER [J].
CHANG, SK ;
DOHRMAN, AF ;
BASBAUM, CB ;
HO, SB ;
TSUDA, T ;
TORIBARA, NW ;
GUM, JR ;
KIM, YS .
GASTROENTEROLOGY, 1994, 107 (01) :28-36
[10]   PARA-NEOPLASTIC VISCERAL NEUROPATHY AS A CAUSE OF SEVERE GASTROINTESTINAL MOTOR DYSFUNCTION [J].
CHINN, JS ;
SCHUFFLER, MD .
GASTROENTEROLOGY, 1988, 95 (05) :1279-1286