Progesterone receptors in reproduction: functional impact of the A and B isoforms

被引：162

作者：

Conneely, OM ^{[1
]}

Lydon, JP ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Cellular & Mol Biol, Houston, TX 77030 USA

来源：

STEROIDS | 2000年 / 65卷 / 10-11期

关键词：

progesterone; receptor; steroid; isoforms;

D O I：

10.1016/S0039-128X(00)00115-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Progesterone (P) is a key regulator of female reproductive activity. The effects of P are mediated by two progesterone receptor (PR) proteins, termed A and B, that arise from a single gene and act as ligand-activated transcription factors to regulate the expression of reproductive target genes. Null mutation of the PR gene in mice (PRKO) leads to pleiotropic reproductive abnormalities. This paper will review the reproductive functions of PRs delineated using the PRKO mouse. Further, we will summarize the structure and functional properties of PRs and discuss how functional differences between the PR-A and PR-B isoforms are likely to impact on the overall physiological role of the receptor in reproductive systems. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：571 / 577

页数：7

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