Comparative current-voltage characteristics of nicked and repaired λ-DNA

被引：45

作者：

Hartzell, B ^{[1
]}

McCord, B

Asare, D

Chen, H

Heremans, JJ

Soghomonian, V

机构：

[1] Ohio Univ, Nanoscale & Quantum Phenomena Inst, Athens, OH 45701 USA

[2] Ohio Univ, Dept Chem & Biochem, Athens, OH 45701 USA

[3] Ohio Univ, Dept Phys & Astron, Athens, OH 45701 USA

来源：

APPLIED PHYSICS LETTERS | 2003年 / 82卷 / 26期

关键词：

D O I：

10.1063/1.1588738

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

We report on current-voltage characteristics obtained at room temperature on lambda-DNA molecules, modified at both ends with disulfide groups and spanning Au electrodes. A comparison is drawn between the characteristics of the lambda-DNA, which after modification features a gap between 3' and 5' sites (nicked DNA), and lambda-DNA where this gap has been ligated (repaired DNA). The repaired DNA double helices show a close-to-linear current-voltage characteristic, and a dc conductivity estimated at similar to1x10(-3) S cm(-1). In contrast, the nicked DNA shows pronouncedly nonlinear and rectifying behavior, with a conductivity gap of similar to3 eV. The low-field conductivity of the nicked DNA is approximately a factor 20 lower than the repaired DNA's conductivity. (C) 2003 American Institute of Physics.

引用

页码：4800 / 4802

页数：3

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