Platelet-activating factor antagonistic activity and 13C NMR assignment of pregomisin and chamigrenal from Schisandra chinensis

被引：28

作者：

Lee, IS

Jung, KY

Oh, SR

Kim, DS

Kim, JH

Lee, JJ

Lee, HK

Lee, SH

Kim, EH

Cheong, C

机构：

[1] Korea Res Inst Biosci & Biotechnol, Nat Prod Biosynthesis Res Unit, Taejon 305600, South Korea

[2] Yeungnam Univ, Coll Pharm, Kyongsan 712749, South Korea

[3] Korea Basic Sci Inst, Magnet Resonance Grp, Taejon 305333, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 1997年 / 20卷 / 06期

关键词：

Schisandra chinensis Baill; Schisandraceae; PAF receptor antagonist; pregomisin; chamigrenal; C-13; NMR;

D O I：

10.1007/BF02975223

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In the course of searching for PAF receptor antagonists, pregomisin (1) and chamigrenal (2) were isolated from the fruits of Schizandra chinensis Baill by the bioactivity-guided isolation. Both compounds showed PAF antagonistic activity and the IC50 values were 4.8 x 10(-5) M and 1.2 x 10(-4) M, respectively. In addition, the C-13 NMR assignments of 1 and 2 using DEPT, HMQC, COLOC and HMBC were reported for the first time.

引用

页码：633 / 636

页数：4

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