Association between variants of mast cell chymase gene and serum IgE levels in eczema

被引：28

作者：

Mao, XQ

Shirakawa, T ^{[1
]}

Enomoto, T

Shimazu, S

Dake, Y

Kitano, H

Hagihara, A

Hopkin, JM

机构：

[1] Churchill Hosp, Osler Chest Unit, Oxford OX3 7LJ, England

[2] Japanese Red Cross Soc, Wakayama Med Ctr, Dept ORL, Wakayama, Japan

[3] Wakayama Natl Hosp, Dept Pediat, Wakayama, Japan

[4] Shiga Univ Med Sci, Dept ORL, Shiga, Japan

[5] Kyushu Univ, Fac Med, Dept Clin Engn, Fukuoka 812, Japan

来源：

HUMAN HEREDITY | 1998年 / 48卷 / 01期

关键词：

eczema; atopy; mast cell chymase; RFLP; IgE;

D O I：

10.1159/000022782

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

851 school children aged at 12-13 years including 145 with eczema were tested for genetic association to a mast cell chymase (MCC) genetic variant. MCC genotypes showed a strong association with eczema, but not with asthma and rhinitis. This association is strongest in eczematous children with lower serum total IgE levels, Independent of IgE responsiveness when total serum IgE of less than 500 IU/ml, MCC variants may play an important role in inflammatory skin disorders.

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页码：38 / 41

页数：4

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