The mechanisms that control intracellular penetration of the HIV protease inhibitors

被引：36

作者：

Hoggard, PG ^{[1
]}

Owen, A ^{[1
]}

机构：

[1] Univ Liverpool, Dept Pharmacol & Therapeut, Liverpool L69 3GE, Merseyside, England

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2003年 / 51卷 / 03期

关键词：

P-glycoprotein; lipophilicity; physiochemical; transport; efflux;

D O I：

10.1093/jac/dkg137

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The PIs are a class of drugs whose members show different physiochemical properties. Because of these properties, the PIs have differential accumulations within cells. As the concentration of free drug at its site of action determines its activity, any mechanism that alters this concentration will alter response. It is therefore essential that these mechanisms are investigated further.

引用

页码：493 / 496

页数：4

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