Camera-based FDG PET and 67Ga SPECT in evaluation of lymphoma:: Comparative study

被引:37
作者
Bar-Shalom, R
Yefremov, N
Haim, N
Dann, EJ
Epelbaum, R
Keidar, Z
Gaitini, D
Frenkel, A
Israel, O [1 ]
机构
[1] Rambam Med Ctr, Dept Nucl Med, IL-35254 Haifa, Israel
[2] Rambam Med Ctr, Dept Oncol, IL-35254 Haifa, Israel
[3] Rambam Med Ctr, Dept Diagnost Radiol, IL-35254 Haifa, Israel
[4] Technion Israel Inst Technol, IL-35254 Haifa, Israel
关键词
fluorine; radioactive; gallium; lymphoma; PET; SPECT; radionuclide imaging; comparative studies;
D O I
10.1148/radiol.2272020195
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
PURPOSE: To compare gallium 67 (Ga-67) scintigraphy and camera-based fluorodeoxyglucose (FDG) positron emission tomography (PET) in the evaluation of patients with lymphoma. MATERIALS AND METHODS: The performance of Ga-67 scintigraphy and camera-based FDG PET in the detection of lymphoma was retrospectively evaluated and compared in 84 patients with lymphoma, with 219 suspected sites of disease. Eighty-nine percent of patients were examined during or after treatment. Camera-3 Camera-based FDG PET was initiated by equivocal characterization of the status of disease based on clinical, radiologic, and Ga-67 scintigraphic assessment. Findings of Ga-67 scintigraphy and camera-based FDG PET were compared on a per-patient and per-site basis for the whole group, for histologic subtypes, and for anatomic locations. Comparison of sensitivity, specificity, and accuracy between the two modalities for detection of lymphoma was performed with the McNemar test. RESULTS: There was a statistically significant difference in sensitivity, specificity, and accuracy of Ga-67 sc intigraphy and camera-based FDG PET at both patient- and site-based analysis. Ga-67 scintigraphy helped to accurately define disease state in 63% of patients and in 33% of sites, compared with 83% and 87%, respectively, for camera-based FDG PET. For discordant findings between the two modalities, camera-based FDG PET findings were confirmed as true-positive in 71% and as true-negative in 92% of patients. Camera-based FDG PET had a significantly higher detection rate for both nodal and extranodal lymphoma sites. It provided accurate assessment of lymphoma involvement of the skeleton in 93% of sites compared with 29% for Ga-67 scintigraphy and excluded active lymphoma in 10 Ga-67-positive benign parahilar sites. CONCLUSION: In this selected group of patients with lymphoma, camera-based FDG PET allowed a significantly more accurate definition of active disease compared with that allowed with Ga-67 scintigraphy.
引用
收藏
页码:353 / 360
页数:8
相关论文
共 40 条
  • [1] Bangerter M, 1999, ACTA ONCOL, V38, P799
  • [2] The value of Ga-67 scintigraphy and F-18 fluorodeoxyglucose positron emission tomography in staging and monitoring the response of lymphoma to treatment
    Bar-Shalom, R
    Mor, M
    Yefremov, N
    Goldsmith, SJ
    [J]. SEMINARS IN NUCLEAR MEDICINE, 2001, 31 (03) : 177 - 190
  • [3] PET imaging in oncology
    Bar-Shalom, R
    Valdivia, AY
    Blaufox, MD
    [J]. SEMINARS IN NUCLEAR MEDICINE, 2000, 30 (03) : 150 - 185
  • [4] BARSHALOM R, 1995, J NUCL MED, V36, P446
  • [5] BENHAIM S, 1995, J NUCL MED, V36, P900
  • [6] Comparison of FDG PET and positron coincidence detection imaging using a dual-head gamma camera with 5/8-inch NaI(Tl) crystals in patients with suspected body malignancies
    Boren, EL
    Delbeke, D
    Patton, JA
    Sandler, MP
    [J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 1999, 26 (04) : 379 - 387
  • [7] Normal physiological and benign pathological variants of 18-fluoro-2-deoxyglucose positron-emission tomography scanning: Potential for error in interpretation
    Cook, GJR
    Fogelman, I
    Maisey, MN
    [J]. SEMINARS IN NUCLEAR MEDICINE, 1996, 26 (04) : 308 - 314
  • [8] SINGLE-PHOTON EMISSION COMPUTED-TOMOGRAPHY QUANTITATION OF GALLIUM CITRATE UPTAKE FOR THE DIFFERENTIATION OF LYMPHOMA FROM BENIGN HILAR UPTAKE
    EVENSAPIR, E
    BARSHALOM, R
    ISRAEL, O
    FRENKEL, A
    IOSILEVSKY, G
    HAIM, N
    EPELBAUM, R
    GAITINI, D
    KOLODNY, GM
    FRONT, D
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1995, 13 (04) : 942 - 946
  • [9] Aggressive non-Hodgkin lymphoma:: Early prediction of outcome with 67Ga scintigraphy
    Front, D
    Bar-Shalom, R
    Mor, M
    Haim, N
    Epelbaum, R
    Frenkel, A
    Gaitini, D
    Kolodny, GM
    Israel, O
    [J]. RADIOLOGY, 2000, 214 (01) : 253 - 257
  • [10] FRONT D, 1993, J NUCL MED, V34, P2101