Serial changes of sensory nerve conduction velocity and minimal F-wave latency in streptozotocin-induced diabetic rats

被引：15

作者：

Kato, N

Makino, M

Mizuno, K

Suzuki, T

Shindo, M

机构：

[1] Sanwa Kagaku Kenkyusho, Dept Res, Pharmaceut Lab, Inabe, Mie 5110406, Japan

[2] Shinshu Univ, Sch Med, Dept Med Neurol, Matsumoto, Nagano 3908621, Japan

来源：

NEUROSCIENCE LETTERS | 1998年 / 244卷 / 03期

关键词：

sensory nerve conduction velocity; caudal nerve; streptozotocin; diabetic rat; minimal F-wave latency; insulin;

D O I：

10.1016/S0304-3940(98)00156-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We studied the serial changes of sensory nerve conduction velocity (SNCV) in the caudal nerve of streptozotocin (STZ)-induced diabetic rats using a new technical method. Minimal F-wave latency was also studied by stimulating the tibial nerve. The SNCV in the diabetic rats was slower than that in the normal rats Z weeks after STZ injection, and minimal F-wave latency was prolonged compared to normal rats 4 weeks after STZ injection. Treatment of the diabetic rats with insulin for 14 days inhibited SNCV slowing and minimal F-wave latency prolongation. This new method to measure SNCV is useful for various studies, and improvement of diabetic neuropathy with insulin treatment is indicated by recovery from SNCV slowing and minimal F-wave latency prolongation. (C) 1998 Elsevier Science Ireland Ltd.

引用

页码：169 / 172

页数：4

共 19 条

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