Caloric restriction attenuates β-amyloid neuropathology in a mouse model of Alzheimer's disease

被引：214

作者：

Wang, J

Ho, L

Qin, WP

Rocher, AB

Seror, I

Humala, N

Maniar, K

Dolios, G

Wang, R

Hof, PR

Pasinetti, GM

机构：

[1] CUNY Mt Sinai Sch Med, Dept Psychiat, Neuroinflammat Res Labs, New York, NY 10029 USA

[2] CUNY Mt Sinai Sch Med, Dept Neurosci, New York, NY 10029 USA

[3] CUNY Mt Sinai Sch Med, Dept Geriatr & Adult Dev, New York, NY 10029 USA

[4] CUNY Mt Sinai Sch Med, Adv Imaging Program, New York, NY 10029 USA

[5] CUNY Mt Sinai Sch Med, Dept Human Genet, New York, NY 10029 USA

来源：

FASEB JOURNAL | 2005年 / 19卷 / 01期

关键词：

AD; A beta neuropathology; neuritic plaque deposition;

D O I：

10.1096/fj.04-3182fje

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study was designed to explore the possibility that caloric restriction (CR) may benefit Alzheimer's disease (AD) by preventing beta-amyloid (Abeta) neuropathology pivotal to the initiation and progression of the disease. We report that a CR dietary regimen prevents Abeta peptides generation and neuritic plaque deposition in the brain of a mouse model of AD neuropathology through mechanisms associated with promotion of anti-amyloidogenic alpha-secretase activity. Study findings support existing epidemiological evidence indicating that caloric intake may influence risk for AD and raises the possibility that CR may be used in preventative measures aimed at delaying the onset of AD amyloid neuropathology.

引用

收藏

页码：659 / +

页数：18

相关论文

共 39 条

[1] The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein [J].

Allinson, TMJ ;

Parkin, ET ;

Condon, TP ;

Schwager, SLU ;

Sturrock, ED ;

Turner, AJ ;

Hooper, NM .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 2004, 271 (12) :2539-2547

[2] Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake [J].

Anson, RM ;

Guo, ZH ;

de Cabo, R ;

Iyun, T ;

Rios, M ;

Hagepanos, A ;

Ingram, DK ;

Lane, MA ;

Mattson, MP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (10) :6216-6220

[3]

Burns M, 2003, J NEUROSCI, V23, P5645

[4] Stereologic assessment of the total cortical volume occupied by amyloid deposits and its relationship with cognitive status in aging and Alzheimer's disease [J].

Bussière, T ;

Friend, PD ;

Sadeghi, N ;

Wicinski, B ;

Lin, GI ;

Bouras, C ;

Giannakopoulos, P ;

Robakis, NK ;

Morrison, JH ;

Perl, DP ;

Hof, PR .

NEUROSCIENCE, 2002, 112 (01) :75-91

[5] Evidence that tumor necrosis factor α converting enzyme is involved in regulated α-secretase cleavage of the Alzheimer amyloid protein precursor [J].

Buxbaum, JD ;

Liu, KN ;

Luo, YX ;

Slack, JL ;

Stocking, KL ;

Peschon, JJ ;

Johnson, RS ;

Castner, BJ ;

Cerretti, DP ;

Black, RA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (43) :27765-27767

[6] Augmented senile plaque load in aged female β-amyloid precursor protein-transgenic mice [J].

Callahan, MJ ;

Lipinski, WJ ;

Bian, F ;

Durham, RA ;

Pack, A ;

Walker, LC .

AMERICAN JOURNAL OF PATHOLOGY, 2001, 158 (03) :1173-1177

[7] Drug therapy - Alzheimer's disease [J].

Cummings, JL .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (01) :56-67

[8] Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo [J].

Farris, W ;

Mansourian, S ;

Chang, Y ;

Lindsley, L ;

Eckman, EA ;

Frosch, MP ;

Eckman, CB ;

Tanzi, RE ;

Selkoe, DJ ;

Guénette, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :4162-4167

[9] An 18-year follow-up of overweight and risk of Alzheimer disease [J].

Gustafson, D ;

Rothenberg, E ;

Blennow, K ;

Steen, B ;

Skoog, I .

ARCHIVES OF INTERNAL MEDICINE, 2003, 163 (13) :1524-1528

[10] Incidence of dementia and Alzheimer disease in 2 communities - Yoruba residing in Ibadan, Nigeria, and African Americans residing in Indianapolis, Indiana [J].

Hendrie, HC ;

Ogunniyi, A ;

Hall, KS ;

Baiyewu, O ;

Unverzagt, FW ;

Gureje, O ;

Gao, SJ ;

Evans, RM ;

Ogunseyinde, AO ;

Adeyinka, AO ;

Musick, B ;

Hui, SL .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (06) :739-747

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