Inhibition of metalloproteinase activity by fruit extracts

被引：37

作者：

Tate, P

God, J

Bibb, R

Lu, Q

Larcom, LL

机构：

[1] Clemson Univ, Dept Phys & Astron, Clemson, SC 29634 USA

[2] Clemson Univ, Dept Biol Sci, Clemson, SC 29634 USA

[3] Dermacon Inc, Conway, SC 29527 USA

来源：

CANCER LETTERS | 2004年 / 212卷 / 02期

关键词：

matrix metalloproteinases; berries; grapes; MMP-2; MMP-9; fruit extracts;

D O I：

10.1016/j.canlet.2004.03.025

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

While the metalloproteinase enzymes are essential for development and remodeling of tissues, aberrant over expression of these enzymes contributes to several pathologic conditions. In particular, metalloproteinase over expression in cancer plays a significant role in metastasis by providing a mechanism for invasion and spread. The data presented here indicate that water extracts of raspberries, blackberries and muscadine grapes inhibit the activities of metalloproteinases 2 and 9. This inhibition could contribute to the suppression of carcinogenesis by diets high in fruit content. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

收藏

页码：153 / 158

页数：6

相关论文

共 32 条

[1] Anti-invasive effects of green tea polyphenol EpiGalloCatechin-3-gallate (EGCG), a natural inhibitor of metallo and serine proteases [J].

Benelli, R ;

Venè, R ;

Bisacchi, D ;

Garbisa, S ;

Albini, A .

BIOLOGICAL CHEMISTRY, 2002, 383 (01) :101-105

[2] Determination of gelatinase-A (MMP-2) activity using a novel immunocapture assay [J].

Capper, SJ ;

Verheijen, J ;

Smith, L ;

Sully, M ;

Visser, H ;

Hanemaaijer, R .

INHIBITION OF MATRIX METALLOPROTEINASES: THERAPEUTIC APPLICATIONS, 1999, 878 :487-490

[3] Inhibitory effect of methanol extract of Euonymus alatus on matrix metalloproteinase-9 [J].

Cha, BY ;

Park, CJ ;

Lee, DG ;

Lee, YC ;

Kim, DW ;

Kim, JD ;

Seo, WG ;

Kim, CH .

JOURNAL OF ETHNOPHARMACOLOGY, 2003, 85 (01) :163-167

[4] MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis [J].

Coussens, LM ;

Tinkle, CL ;

Hanahan, D ;

Werb, Z .

CELL, 2000, 103 (03) :481-490

[5] Interactions between tumour cells and stromal cells and proteolytic modification of the extracellular matrix by metalloproteinases in cancer [J].

DeClerck, YA .

EUROPEAN JOURNAL OF CANCER, 2000, 36 (10) :1258-1268

[6] Matrix metalloproteinase inhibition by green tea catechins [J].

Demeule, M ;

Brossard, M ;

Pagé, M ;

Gingras, D ;

Béliveau, R .

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, 2000, 1478 (01) :51-60

[7]

Garbisa S, 2001, CANCER-AM CANCER SOC, V91, P822, DOI 10.1002/1097-0142(20010215)91:4<822::AID-CNCR1070>3.0.CO

[8]

2-G

[9] A novel and simple immunocapture assay for determination of gelatinase-B (MMP-9) activities in biological fluids: Saliva from patients with Sjogren's syndrome contain increased latent and active gelatinase-B levels [J].

Hanemaaijer, R ;

Visser, H ;

Konttinen, YT ;

Koolwijk, P ;

Verheijen, JH .

MATRIX BIOLOGY, 1998, 17 (8-9) :657-665

[10]

Heppner KJ, 1996, AM J PATHOL, V149, P273

← 1 2 3 4 →