HLA-class I markers and multiple sclerosis susceptibility in the Italian population

被引：37

作者：

Bergamaschi, L. ^{[2
]}

Leone, M. A. ^{[3
]}

Fasano, M. E. ^{[4
]}

Guerini, F. R. ^{[5
]}

Ferrante, D. ^{[1
,6
]}

Bolognesi, E. ^{[2
]}

Barizzone, N. ^{[2
]}

Corrado, L. ^{[2
]}

Naldi, P. ^{[3
]}

Agliardi, C. ^{[5
]}

Dametto, E. ^{[4
]}

Salvetti, M. ^{[7
]}

Visconti, A. ^{[7
]}

Galimberti, D. ^{[8
]}

Scarpini, E. ^{[8
]}

Vercellino, M. ^{[9
]}

Bergamaschi, R. ^{[10
]}

Monaco, F. ^{[3
,11
]}

Caputo, D. ^{[12
]}

Momigliano-Richiardi, P. ^{[2
]}

D'Alfonso, S. ^{[1
,2
]}

机构：

[1] Univ Piemonte Orientale, Dept Med Sci, Unit Med Stat & Canc Epidemiol, I-28100 Novara, Italy

[2] Univ Piemonte Orientale, IRCAD, I-28100 Novara, Italy

[3] Osped Maggiore Novara, Dept Neurol, Novara, Italy

[4] San Giovanni Battista Hosp, Turin, Italy

[5] IRCCS, Don C Gnocchi Fdn, Lab Mol Med & Biotechnol, Milan, Italy

[6] CPO Piemonte, Novara, Italy

[7] Univ Roma La Sapienza, Ctr Expt Neurol Therapy CENTERS, Rome, Italy

[8] Univ Milan, Fdn Osped Maggiore Policlin, Dino Ferrari Ctr, Dept Neurol Sci, Milan, Italy

[9] Osped San Giovanni Battista Torino, Dept Neurol, Turin, Italy

[10] IRCCS, Neurol Inst C Mondino, Pavia, Italy

[11] Univ Piemonte Orientale, Dept Clin & Expt Med, I-28100 Novara, Italy

[12] IRCCS, Don C Gnocchi Fdn, Multiple Sclerosis Unit, Milan, Italy

来源：

GENES AND IMMUNITY | 2010年 / 11卷 / 02期

关键词：

multiple sclerosis; HLA-class I markers; extended HLA haplotypes; Myelin Oligodendrocyte Glycoprotein; genetic association; MAJOR HISTOCOMPATIBILITY COMPLEX; MHC HAPLOTYPES; ASSOCIATION; DISEASE; RISK; GENE; DISEQUILIBRIUM; CONFIRMATION; CONFERS; REGION;

D O I：

10.1038/gene.2009.101

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Previous studies reported an association with multiple sclerosis (MS) of distinct HLA-class I markers, namely HLA-A*02, HLA-Cw*05 and MOG-142L. In this work, we tested the association with MS of A*02 and Cw*05 in 1273 Italian MS patients and 1075 matched controls, which were previously analyzed for MOG-142, and explored the relationship among these three markers in modulating MS risk. HLA-A*02 conferred a statistically robust MS protection (odds ratio, OR=0.61; 95% confidence intervals, CI=0.51-0.72, P<10(-9)), which was independent of DRB1*15 and of any other DRB1* allele and remained similar after accounting for the other two analyzed class I markers. Conversely, the protective effect we previously observed for MOG-142L was secondary to its linkage disequilibrium with A*02. Cw*05 was not associated considering the whole sample, but its presence significantly enhanced the protection in the HLA-A*02-positive group, independently of DRB1: the OR conferred by A*02 in Cw*05-positive individuals (0.22, 95% CI=0.13-0.38) was significantly lower than in Cw*05-negative individuals (0.69, 95% CI=0.58-0.83) with a significant (P=4.94 x 10(-5)) multiplicative interaction between the two markers. In the absence of A*02, Cw*05 behaved as a risk factor, particularly in combination with DRB1* 03 (OR=3.89, P=0.0006), indicating that Cw*05 might be a marker of protective or risk haplotypes, respectively. Genes and Immunity (2010) 11, 173-180; doi: 10.1038/gene.2009.101; published online 12 November 2009

引用

页码：173 / 180

页数：8

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