Essential role for autophagy in life span extension

被引：395

作者：

Madeo, Frank ^{[1
,2
]}

Zimmermann, Andreas ^{[1
]}

Maiuri, Maria Chiara ^{[3
]}

Kroemer, Guido ^{[3
,4
,5
,6
]}

机构：

[1] Graz Univ, NAWI Graz, Inst Mol Biosci, A-8010 Graz, Austria

[2] BioTechMed, Graz, Austria

[3] Ctr Rech Cordeliers, INSERM, U1138, Paris, France

[4] Inst Gustave Roussy, Villejuif, France

[5] Univ Paris 05, Sorbonne Paris Cite, Paris, France

[6] Hop Europeen Georges Pompidou, AP HP, Pole Biol, Paris, France

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2015年 / 125卷 / 01期

基金：

欧洲研究理事会; 奥地利科学基金会;

关键词：

CALORIC RESTRICTION; SELECTIVE AUTOPHAGY; REGULATES AUTOPHAGY; DIETARY RESTRICTION; ADIPOSE-TISSUE; RAPAMYCIN; LONGEVITY; PROTEINS; STRESS; HEALTH;

D O I：

10.1172/JCI73946

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Life and health span can be prolonged by calorie limitation or by pharmacologic agents that mimic the effects of caloric restriction. Both starvation and the genetic inactivation of nutrient signaling converge on the induction of autophagy, a cytoplasmic recycling process that counteracts the age-associated accumulation of damaged organelles and proteins as it improves the metabolic fitness of cells. Here we review experimental findings indicating that inhibition of the major nutrient and growth-related signaling pathways as well as the upregulation of anti-aging pathways mediate life span extension via the induction of autophagy. Furthermore, we discuss mounting evidence suggesting that autophagy is not only necessary but, at least in some cases, also sufficient for increasing longevity.

引用

页码：85 / 93

页数：9

共 106 条

[1]

Why do the well-fed appear to die young? [J].

Adler, Margo I. ;

Bonduriansky, Russell .

BIOESSAYS, 2014, 36 (05) :439-450

[2]

Label-free detection and dynamic monitoring of drug-induced intracellular vesicle formation enabled using a 2-dimensional matched filter [J].

Aftab, Obaid ;

Fryknas, Marten ;

Zhang, Xiaonan ;

De Milito, Angelo ;

Hammerling, Ulf ;

Linder, Stig ;

Larsson, Rolf ;

Gustafsson, Mats G. .

AUTOPHAGY, 2014, 10 (01) :57-69

[3]

Resveratrol improves health and survival of mice on a high-calorie diet [J].

Baur, Joseph A. ;

Pearson, Kevin J. ;

Price, Nathan L. ;

Jamieson, Hamish A. ;

Lerin, Carles ;

Kalra, Avash ;

Prabhu, Vinayakumar V. ;

Allard, Joanne S. ;

Lopez-Lluch, Guillermo ;

Lewis, Kaitlyn ;

Pistell, Paul J. ;

Poosala, Suresh ;

Becker, Kevin G. ;

Boss, Olivier ;

Gwinn, Dana ;

Wang, Mingyi ;

Ramaswamy, Sharan ;

Fishbein, Kenneth W. ;

Spencer, Richard G. ;

Lakatta, Edward G. ;

Le Couteur, David ;

Shaw, Reuben J. ;

Navas, Placido ;

Puigserver, Pere ;

Ingram, Donald K. ;

de Cabo, Rafael ;

Sinclair, David A. .

NATURE, 2006, 444 (7117) :337-342

[4]

The LIR motif - crucial for selective autophagy [J].

Birgisdottir, Asa Birna ;

Lamark, Trond ;

Johansen, Terje .

JOURNAL OF CELL SCIENCE, 2013, 126 (15) :3237-3247

[5]

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster [J].

Bjedov, Ivana ;

Toivonen, Janne M. ;

Kerr, Fiona ;

Slack, Cathy ;

Jacobson, Jake ;

Foley, Andrea ;

Partridge, Linda .

CELL METABOLISM, 2010, 11 (01) :35-46

[6]

Long-term Administration of Rapamycin Reduces Adiposity, but Impairs Glucose Tolerance in High-Fat Diet-fed KK/HlJ Mice [J].

Chang, Geng-Ruei ;

Wu, Ying-Ying ;

Chiu, Yi-Shin ;

Chen, Wen-Ying ;

Liao, Jiunn-Wang ;

Hsu, Hong-Ming ;

Chao, Te-Hsin ;

Hung, Siu-Wan ;

Mao, Frank Chiahung .

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2009, 105 (03) :188-198

[7]

Autophagy: Emerging roles in lipid homeostasis and metabolic control [J].

Christian, Patricia ;

Sacco, Jennifer ;

Adeli, Khosrow .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2013, 1831 (04) :819-824

[8]

Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells [J].

Chu, Charleen T. ;

Ji, Jing ;

Dagda, Ruben K. ;

Jiang, Jian Fei ;

Tyurina, Yulia Y. ;

Kapralov, Alexandr A. ;

Tyurin, Vladimir A. ;

Yanamala, Naveena ;

Shrivastava, Indira H. ;

Mohammadyani, Dariush ;

Wang, Kent Zhi Qiang ;

Zhu, Jianhui ;

Klein-Seetharaman, Judith ;

Balasubramanian, Krishnakumar ;

Amoscato, Andrew A. ;

Borisenko, Grigory ;

Huang, Zhentai ;

Gusdon, Aaron M. ;

Cheikhi, Amin ;

Steer, Erin K. ;

Wang, Ruth ;

Baty, Catherine ;

Watkins, Simon ;

Bahar, Ivet ;

Bayir, Huelya ;

Kagan, Valerian E. .

NATURE CELL BIOLOGY, 2013, 15 (10) :1197-U168

[9]

CELLULAR DIFFERENTIATION IN THE KIDNEYS OF NEWBORN MICE STUDIED WITH THE ELECTRON MICROSCOPE [J].

CLARK, SL .

JOURNAL OF BIOPHYSICAL AND BIOCHEMICAL CYTOLOGY, 1957, 3 (03) :349-&

[10]

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys [J].

Colman, Ricki J. ;

Anderson, Rozalyn M. ;

Johnson, Sterling C. ;

Kastman, Erik K. ;

Kosmatka, Kristopher J. ;

Beasley, T. Mark ;

Allison, David B. ;

Cruzen, Christina ;

Simmons, Heather A. ;

Kemnitz, Joseph W. ;

Weindruch, Richard .

SCIENCE, 2009, 325 (5937) :201-204

← 1 2 3 4 5 6 7 8 9 10 →